Anti-Inflammatory Immune Skewing Is Atheroprotective: Apoe-/-Fc{gamma}RIIb-/- Mice Develop Fibrous Carotid Plaques [Vascular Medicine]

Conclusions
We hypothesized that removal of FcRIIb would exacerbate atherosclerosis and generate unstable plaques. However, we found that deletion of FcRIIb on a congenic C57BL/6 background induces an anti-inflammatory Treg/M2 polarization that is atheroprotective.

Source: JAHA:Journal of the American Heart Association - December 16, 2014 Category: Cardiology Authors: Harmon, E. Y., Fronhofer, V., Keller, R. S., Feustel, P. J., Zhu, X., Xu, H., Avram, D., Jones, D. M., Nagarajan, S., Lennartz, M. R. Tags: Vascular Medicine Source Type: research