Serum IL-36 α, IL-36β, and IL-36γ levels in patients with hidradenitis suppurativa: association with disease characteristics, smoking, obesity, and metabolic syndrome

AbstractHidradenitis Suppurativa (HS) is a chronic, inflammatory, and relapsing skin disease. Pathogenesis of the disease is not well understood, but many studies revealed the potential role of cytokines and interleukins. IL-36 expression was increased in tissue samples of HS patients with conflicting result regarding serum levels. To investigate serum IL-36 levels in HS patients and evaluate their relation to disease characteristics, 44 patients diagnosed with HS and 44 age and sex-matched healthy controls were included in the study. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-36 concentrations. Serum levels of IL-36 α, IL-36β, and IL-36γ were significantly elevated in HS patients compared to healthy controls (all threep 
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research

Related Links:

Discussion Hidradenitis suppurativa (HS) is a recurrent, chronic inflammatory disease of the hair follicles particularly in the apocrine gland-bearing areas of the axilla, inguinal, perianal, mammary and inframammary areas. Onset is usually after puberty, in the early 20s. It is more common in females than males. Prevalence is estimated to be 0.05- 4.1%. It can be associated with premature adrenarche, metabolic syndrome and obesity. The lesions are often pruritic, painful, and with malodorous purulent drainage. It often begins with comedomes and tender nodules, and can easily progress to painful abscesses with purulent f...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Background: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. Other chronic inflammatory diseases have been linked with metabolic syndrome. However, it is unclear whether this association is independent or driven by underlying risk factors and comorbidities in common, such as obesity, dyslipidemia, hyperglycemia and hypertension.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Introduction: Hidradenitis suppurativa (HS) is a debilitating and distressing chronic inflammatory skin disease. It is characterized by recurrent, painful, deep-seated skin nodules which can be complicated by abscesses formation, sinus tracks, fistulae and scarring. There is also evolving evidence supporting the association between HS and cardiovascular risk factors, including smoking, obesity, hyperlipidaemia, and metabolic syndrome. Notably, these are clinical features and risk factors that are closely associated with type 2 diabetes mellitus (DM).
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Purpose of review Several chronic inflammatory skin disorders have been linked to metabolic syndrome (MetS) and an increased risk for cardiovascular disease. In this review, we will summarize the recent evidence on the association between psoriasis, hidradenitis suppurativa (HS), and atopic dermatitis (AD) and metabolic syndrome with careful attention to this association among the pediatric population. Recent findings Historically, psoriasis has exhibited the most robust association with MetS in the literature. Recent studies show that the prevalence of MetS appears to be higher among patients with HS and can be assoc...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GENETICS OF VASCULAR MALFORMATION AND THERAPEUTIC IMPLICATIONS: Edited by Joyce M.C. Teng Source Type: research
CONCLUSION: Metformin is an effective, well tolerated and inexpensive treatment, that represents a viable treatment option for HS. Key message: Metformin is an effective, well tolerated and inexpensive treatment in the management of HS. PMID: 30893570 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Pescitelli L, Ricceri F, Prignano F Abstract Hidradenitis suppurativa is a chronic, inflammatory, recurrent, debilitating skin disease characterized by recurrent abscesses, draining sinuses, and scarring, affecting principally areas of body friction. Although the disease pathogenesis is not fully understood, recent advances suggest that hidradenitis suppurativa should be viewed as a systemic inflammatory disease. Moreover, recent studies have defined hidradenitis suppurativa as a systemic disease linked to several comorbidities. Metabolic disorders including obesity and metabolic syndrome are the most comm...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
CONCLUSIONS: HS is associated with a variety of comorbid conditions that should be considered to perform targeted routine screening and to improve HS management. PMID: 30295448 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
This study indicates that HS patients have higher SVLs, SILs, and hs-CRP levels than healthy controls—independent of BMI and smoking status. The SVL and SILs and smoking were independent risk factors for HS.
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research
The objective of our study is to estimate the effectiveness of an oral supplementation based on myo- inositol (MI), folic acid and liposomal magnesium (LEVIGON®) on the clinical and metabolic profile of patients affected by HS. METHODS: 20 subjects with HS and an impaired glucose metabolism were enrolled. Group A: 10 subjects received for 6 months MI 2000 mg, liposomal magnesium and folic acid associated to topical antibiotic therapy (clindamycin gel 1%), systemic antibiotic therapy (clindamycin 300 mg b.i.d. and rifampicin 600 mg daily for 6 weeks) and a normocaloric diet Group B: 10 subjects received topical and ...
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
Introduction: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder with painful lesions in apocrine gland-bearing regions of the body, and is often associated with conditions such as obesity and metabolic syndrome. The safety and efficacy of adalimumab (ADA) in the treatment of patients with HS has been demonstrated in 2 double-blind phase 3 trials. However, the effects of ADA on metabolic factors have not yet been examined.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
More News: Dermatology | Eating Disorders & Weight Management | Hidradenitis | Metabolic Syndrome | Obesity | Skin | Smokers | Study