Serum IL-36 α, IL-36β, and IL-36γ levels in patients with hidradenitis suppurativa: association with disease characteristics, smoking, obesity, and metabolic syndrome

AbstractHidradenitis Suppurativa (HS) is a chronic, inflammatory, and relapsing skin disease. Pathogenesis of the disease is not well understood, but many studies revealed the potential role of cytokines and interleukins. IL-36 expression was increased in tissue samples of HS patients with conflicting result regarding serum levels. To investigate serum IL-36 levels in HS patients and evaluate their relation to disease characteristics, 44 patients diagnosed with HS and 44 age and sex-matched healthy controls were included in the study. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum IL-36 concentrations. Serum levels of IL-36 α, IL-36β, and IL-36γ were significantly elevated in HS patients compared to healthy controls (all threep <  0.001). IL-36α, IL-36β, and IL-36γ levels were significantly higher in current smokers compared to non-smokers and positively correlated with number of packs/year (p = 0.002,r = 0.402;p = 0.042,r = 0.242 andp = 0.001,r = 0.391, respectively). IL-36α, IL-36β, and IL-36γ levels were also elevated in obese patients and patients with metabolic syndrome (p = 0.007, <  0.001, 0.038, 0.004, 0.006, and 0.048, respectively). After stratified and restricted analyses for smoking, obesity, and metabolic syndrome IL-36α, IL-36β, and IL-36γ increased the risk of HS 11.0, 1.79, and 4.5 time, respectively (95% CI 1.7–71.28,p <  0.001; 95% CI 1.04–3.06,p = 0.005 and, 95% CI 1.0...
Source: Archives of Dermatological Research - Category: Dermatology Source Type: research