Epidemiologic trends and geographic distribution of esophageal cancer in Canada: A national population ‐based study

ConclusionsThis study, for the first time, provides a detailed analysis on the burden of esophageal cancer in Canada, revealing important geographic clustering trends.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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ConclusionPost-diagnosis PPI/H2RA use was associated with the increased mortality in gastric non-cardia cancer and HCC patients.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Conditions:   Clinical Stage 0 Esophageal Adenocarcinoma AJCC v8;   Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage I Esophageal Adenocarcinoma AJCC v8;   Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage II Esophageal Adenocarcinoma AJCC v8;   Cl inical Stage II Esophageal Squamous Cell Carcinoma AJCC v8;   Clinical Stage IIA Esophageal Adenocarcinoma AJCC v8;   Clinical Stage IIB Esophageal Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Adenocarcinoma AJCC v8;   Clinical Stage III Esophageal Squamous Cell ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Comparison of detection rates of esophageal squamous cell carcinoma (ESCC) and gastric adenocarcinoma (GA) according to age groups and ALDH2 genotype between the 1993 ‐2007 screening period and the 2008‐2018 screening period in Japanese alcohol‐dependent men. The detection rates for ESCC and GA were consistently lower during the 2008‐2018 study period than during the 1993‐2007 study period regardless of age groups and ALDH2 genotype. AbstractBackgroundEsophageal squamous cell carcinoma (ESCC), head and neck SCC (HNSCC), and gastric adenocarcinoma (GA) are frequently detected at an early stage using endoscopic scr...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractEsophageal cancer (EC) is one of the most lethal malignancies of the digestive tract and remains to be improved poor prognosis. Two histological subtypes, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), are major characteristics of EC. Deep understanding about both subtypes is essential to overcome EC. Here, we focus on chemokines and their receptors as biomarkers and their current applications for the prognosis in EC. We reviewed relevant articles identified using PubMed database for the chemokines and their receptors in EC analyzed by immunohistochemistry. The primary objective is t...
Source: Esophagus - Category: Gastroenterology Source Type: research
Whereas the incidence of esophageal adenocarcinoma is increasing in Western countries, squamous cell carcinoma remains the main histological type of esophageal cancer in Japan (88.3%).1 The nationwide Japanese registry shows that both the frequency of nodal metastasis and efficacy index of lymphadenectomy are highest for the upper mediastinal nodal station in patients with upper (42.9%, 17.6; respectively) and middle (37.4%, 15.0; respectively) esophageal cancer.2 Recurrent laryngeal nerve (RLN) palsy is one of the most feared complications in patients with esophageal cancer who undergo esophagectomy plus meticulous upper ...
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Surgeon at Work Source Type: research
Hamilton Whelan Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of <20%. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles and misfolded proteins to maintain cellular homeostasis. While alterations in autophagy have been associated with carcinogenesis across tissues, cell type- and context-dependent roles for autophagy have been reported. Herein, we review the current knowledge related to autophagy in esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), the two most common ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
This study aimed to evaluate the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer using the Surveillance, Epidemiology, and End Results database. Additionally, we constructed prognostic nomograms for both preoperative and postoperative risk factors. We found that palliative resection or radiation could improve the survival of such patients, across both squamous cell carcinoma and adenocarcinoma. AbstractPurposeWe aimed to explore the value of palliative resection or radiation of primary tumor for metastatic esophageal cancer (EC) patients.MethodsSurveillance, Epidemiology, and En...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Chen D, Fan N, Mo J, Wang W, Wang R, Chen Y, Hu J, Wen Z Abstract Background: Patients with esophageal cancer (EC) frequently have multiple primary cancers. We conducted the present study to assess the risk of multiple primary malignancies for patients with squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus and to investigate the influence of multiple primary tumors on the prognosis of EC patients. Methods: Using the data of 44,091 EC patients from the Surveillance Epidemiology and End Results (SEER) database, we calculated the standardized incidence ratios (SIRs) for overall multip...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Abstract Esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EGJA) are the two main types of gastrointestinal cancers that pose a huge threat to human health. ESCC remains one of the most common malignant diseases around the world. In contrast to the decreasing prevalence of ESCC, the incidence of EGJA is rising rapidly. Early detection represents one of the most promising ways to improve the prognosis and reduce the mortality of these cancers. Current approaches for early diagnosis mainly depend on invasive and costly endoscopy. Non-invasive biomarkers are in great need to facil...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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