New York Identifies Hospitals and Nursing Homes With Deadly Fungus

The policy change, for the virulent drug-resistant germ Candida auris, came as the C.D.C. reported that more people are dying of drug-resistant infections than it previously estimated.
Source: NYT - Category: American Health Authors: Tags: Drug Resistance (Microbial) Candida Auris (Fungus) Antibiotics Infections Hospitals Nursing Homes Medicine and Health States (US) Centers for Disease Control and Prevention New York State Source Type: news

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There are only few drugs available to treat fungal infections, and the lack of new antifungals, along with the emergence of drug-resistant strains, results in millions of deaths/year. An unconventional approach to fight microbial infection is to exploit nutritional vulnerabilities of microorganism metabolism. The metal gallium can disrupt iron metabolism in bacteria and cancer cells, but it has not been tested against fungal pathogens such as Aspergillus and Candida. Here, we investigate in vitro activity of gallium nitrate III [Ga(NO3)3] against these human pathogens, to reveal the gallium mechanism of action and understa...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
ConclusionsPMMA acrylic resin base material was superficially modified through the incorporation of carboxylic acid groups by using PAA and PIA coatings that reduced the adherence of C albicans biofilm by 90%.
Source: The Journal of Prosthetic Dentistry - Category: Dentistry Source Type: research
Authors: Casagrande Pierantoni D, Bernardo M, Mallardo E, Carannante N, Attanasio V, Corte L, Roscini L, Di Fiore L, Tascini C, Cardinali G Abstract A correct, fast, reliable identification method is pivotal in nosocomial environments to guide treatment strategies, whereas misidentification might lead to treatment failure. For routine identifications the Vitek system and CHROMagar are widely used but not always reliable, especially now with an increasing number of new emerging fungal pathogens that need careful identification. Here we describe two cases of candidemia, due to Candida palmioleophila previously miside...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Publication date: Available online 9 December 2019Source: PolymerAuthor(s): O.I. Timaeva, N.A. Arkharova, A.S. Orekhov, V.V. Klechkovskaya, S.P. Mulakov, G.M. Kuz'micheva, I.I. PashkinAbstractComposite hydrogels in the poly-N-vinylpyrrolidone – RE(NO3)3 × xH2O system with RE = La, Gd, Yb were prepared in various forms (native, native dried in the air, dried in air and ground into powder). They were studied by methods of wide- and small-angle X-ray scattering, differential scanning calorimetry, scanning electron microscopy, and electron microprobe analysis. The composition of native PVP and PVP with powd...
Source: Polymer - Category: Chemistry Source Type: research
Kawasaki disease (KD) is a systemic febrile syndrome during childhood that is characterized by coronary arteritis. The etiopathogenesis of KD remains to be elucidated. NLRP3 inflammasome is a large multiprotein complex that plays a key role in IL-1 β-driven sterile inflammatory diseases. In the present study, we investigated the role of NLRP3 inflammasome in a murine model of KD induced by Candida albicans water-soluble fraction (CAWS) and found that NLRP3 inflammasome is required for the development of CAWS-induced vasculitis.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
The Centers for Disease Control and Prevention (CDC) has recently identified medical devices used in the ICU as a major source of antibiotic-resistant infections. N8 Medical’s CeraShield technology may help reduce such infections by preventing fouling and formation of bacterial and fungal biofilms on device surfaces. FDA has designated the company’s CeraShield Endotracheal Tube (ETT) as a “breakthrough” device, pursuant to the 21st Century Cures Act based on its potential life-saving properties. And N8 reported that ...
Source: MDDI - Category: Medical Devices Authors: Tags: Materials Source Type: news
AbstractAimsSacubitril/valsartan has shown efficacy and tolerability in patients with heart failure (HF) and reduced ejection fraction (HFrEF) in the ambulatory setting (PARADIGM ‐HF), and following stabilisation of acutely decompensated HF (ADHF) (PIONEER‐HF and TRANSITION). However, data are lacking for the initiation of sacubitril/valsartan in newly diagnosed (de novo) HFrEF. Here, we assess the tolerability of initiating sacubitril/valsartan following ADHF in TRANSITION subgroups of patients with ade novo vs. prior diagnosis of HFrEF.Methods and resultsTRANSITION randomised 1002 patients to pre ‐ and post‐disch...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
This study presents a device for efficient, low-cost and eye-friendly overnight disinfection of contact lenses by visible violet light as an alternative to disinfection with biocide-containing solutions. Bacterial solutions with one Pseudomonas and one Staphylococcus strain each were irradiated for up to 8 h in commercial transparent contact lens cases by the presented light-emitting diode (LED) device. Samples were taken at different intervals and distributed on agar plates. The surviving bacteria were determined by counting of colony-forming units and compared to the specific requirements of the stand-alone test for cont...
Source: Biomedizinische Technik/Biomedical Engineering - Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research
In conclusion, here we report that, in addition to macropexophagy, peroxisomes damaged by PA1 can be eliminated by micropexophagy. This information is useful to deepen in the knowledge of the mechanism of action of PA1 and in that of pexophagy per se. This article is protected by copyright. All rights reserved. PMID: 31814220 [PubMed - as supplied by publisher]
Source: Cell Biology International - Category: Cytology Authors: Tags: Cell Biol Int Source Type: research
In conclusion, the results suggest that, because of its bioactivity including the antioxidant, antimicrobial, and enzyme inhibition properties, the D. macrolepis can be accepted as a promising and natural source for the industrial applications. The present study is the first study, in which the bioactive components and the antioxidant, antimicrobial, and enzyme inhibition properties of endemic D. macrolepis plant were determined.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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