Wnt5a promotes differentiation and development of adult ‐born neurons in the hippocampus by non‐canonical Wnt signaling

This study demonstrates that Wnt5a is a neurogenic factor that promotes neuronal differentiation and morphological development of adult ‐born neurons in the hippocampus. Results indicate that Wnt5a signals through CaMKII to induce neuronal differentiation, and induces dendritic development of newborn neurons through Wnt/JNK and Wnt/CaMKII pathways. Together, these findings identify Wnt5a as an endogenous non‐canonical Wnt ligand regulating adult hippocampal neurogenesis.

Source: Stem Cells - November 12, 2019 Category: Stem Cells Authors: Sebastian B. Arredondo, Fernanda G. Guerrero, Andrea Herrera ‐Soto, Joaquin Jensen‐Flores, Daniel B. Bustamante, Alejandro Oñate‐Ponce, Pablo Henny, Manuel Varas‐Godoy, Nibaldo C. Inestrosa, Lorena Varela‐Nallar Tags: Tissue ‐Specific Stem Cells Source Type: research