A histone deacetylase 7 ‐derived peptide promotes vascular regeneration via facilitating 14‐3‐3γ phosphorylation

This study provides evidence that sORFs can be alternatively translated and the derived peptides may play an important role in physiological processes including vascular remodeling.© AlphaMed Press 2019Significance StatementHistone deacetylase 7 (HDAC7) plays a pivotal role in the maintenance of the endothelial integrity. Short open reading frames (sORFs) exist within the 5 ′ terminal non‐coding area of Hdac7 mRNA. It remains unclear whether these sORFs contribute to HADC7 functions. In this study, we demonstrated that a 7‐amino acid peptide could be translated from a sORF. This peptide could act as phosphate group carrier, forming a novel signal transduction pat hway, the MEKK1‐7A‐14‐3‐3? pathway, downstream VEGF. The novel signal pathway may be involved in vessel wall resident stem/progenitor cell activation and vascular remodeling.

Source: Stem Cells - November 12, 2019 Category: Stem Cells Authors: Junyao Yang, Ana Moraga, Jing Xu, Yue Zhao, Peiyi Luo, Ka Hou Lao, Andriana Margariti, Qiang Zhao, Wei Ding, Gang Wang, Min Zhang, Lei Zheng, Zhongyi Zhang, Yanhua Hu, Wen Wang, Lisong Shen, Alberto Smith, Ajay M Shah, Qian Wang, Lingfa Tags: Tissue ‐Specific Stem Cells Source Type: research