Co-administration of omega-3 fatty acids and metformin showed more desirable effects than the single therapy on indices of bone mineralisation but not gluco-regulatory and antioxidant markers in diabetic rats.

Co-administration of omega-3 fatty acids and metformin showed more desirable effects than the single therapy on indices of bone mineralisation but not gluco-regulatory and antioxidant markers in diabetic rats. Biomed Pharmacother. 2019 Nov 09;121:109631 Authors: Adeyemi WJ, Olayaki LA, Abdussalam TA, Fabiyi TO, Raji TL, Adetunji AA Abstract Although metformin (Met) is the most recommended anti-diabetogenic drug in type 2 diabetic state, the drug is known to compromise bone integrity. Like metformin, omega-3 fatty acids (ω-3) have gluco-regulatory action; however, it aids bone health. Therefore, the present study investigated the effects of ω-3 and/or metformin in diabetic rats. Fifty rats of ten animals per group were divided into the following: Control; Diabetic untreated; Diabetic + ω-3; Diabetic + metformin (metfm) and Diabetic + ω-3 + metf groups. Diabetes was induced by the administration of streptozotocin (65 mg/kg b.w., i.p.), 15 min after the administration of nicotinamide (110 mg/kg b.w., i.p.). Five days afterwards, treatments started and they lasted for 28 days. ω-3 and metformin were administered at 200 and 180 mg/kg b.w., p.o. respectively. The results showed that the induced diabetes was characterised by significant increases in calcium to phosphorus ratio, tartrate resistant acid phosphatase (TRAP), glucose and insulin resistance; but significant decreases in parathyroid hormone(PTH), phosphorus, T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research

Related Links:

ConclusionsFor closed-circuit dialysis using an RBC solution, the formula [dialysate flow rate (mL/min)  × time of dialysis (min)]/extracorporeal volume (mL) would be a better parameter to estimate efficacy, compared with other metrics. Additionally, the citrate concentration can be readily estimated from the ionized calcium concentration during closed-circuit dialysis.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
CONCLUSIONS Silicone oil endotamponade in PPV was associated with an increased risk of IOP at 24-month follow-up. PMID: 31811816 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Protective Effect of β-Glucogallin on Damaged Cataract Against Methylglyoxal Induced Oxidative Stress in Cultured Lens Epithelial Cells. Med Sci Monit. 2019 Dec 07;25:9310-9318 Authors: Ma Y, Liu F, Xu Y Abstract BACKGROUND ß-glucogallin (GG) is one of the major plant polyphenolic antioxidants that have been associated with positive effects on human health and are crucial in the developing defense mechanism against the risk of diseases. However, reports on the protective mechanism of GG in lens epithelial cells are limited. MATERIAL AND METHODS ARPE-19 cells (a human retinal epithelial cell ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, these results showed that supplementing PFEA could relieve fatigue effects.Graphical abstractThis study was performed to evaluate the characteristics of purified anthocyanin from purple passion fruit exocarps (PFEA) as well as its anti-fatigue activity in mice.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Milkica Grabež, Ranko Škrbić, Miloš P. Stojiljković, Vesna Rudić-Grujić, Marija Paunović, Aleksandra Arsić, Snježana Petrović, Vesna Vučić, Bosa Mirjanić-Azarić, Katarina Šavikin, Nebojša Menković, Teodora Janković, Nađa VasiljevićAbstractPomegranate peel contains high levels of various phytochemicals. We evaluated the effects of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) level and blood pressure (BP) in patients with diabetes mellitus type ...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: January 2020Source: Biomedicine &Pharmacotherapy, Volume 121Author(s): Wale Johnson Adeyemi, Luqman Aribidesi Olayaki, Tahir Ahmad Abdussalam, Tolulope Olaoluwa Fabiyi, Temidayo Luqman Raji, Adenike Amatur-Rahman AdetunjiAbstractAlthough metformin (Met) is the most recommended anti-diabetogenic drug in type 2 diabetic state, the drug is known to compromise bone integrity. Like metformin, omega-3 fatty acids (ω-3) have gluco-regulatory action; however, it aids bone health. Therefore, the present study investigated the effects of ω-3 and/or metformin in diabetic rats. Fifty rats of ten anima...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Discussion Suppressor of cytokine signaling 1 is an essential molecule for maintaining immune homeostasis and subverting inflammation. Disorders arising from excess inflammation or SOCS1 deficiency can be potentially treated with SOCS1 mimetics (Ahmed et al., 2015). While SOCS1 has promising potential in many disorders, it should be noted that new targets and actions of SOCS1 are still being discovered and not all the effects of this protein are beneficial in autoimmune diseases and cancer. For instance, SOCS1 degrades IRS1 and IRS2, required for insulin signaling, via the SOCS Box domain, thus, limiting its potential in ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study showed that potential vicious cycles underlying ARDs are quite diverse and unique, triggered by diverse and unique factors that do not usually progress with age, thus casting doubts on the possibility of discovering the single molecular cause of aging and developing the single anti-aging pill. Rather, each disease appears to require an individual approach. However, it still cannot be excluded that some or all of these cycles are triggered by fundamental processes of aging, such as chronic inflammation or accumulation of senescent cells. Nevertheless, experimental data showing clear cause and effect relationships...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: People with HIV were more likely to have a poor mental HRQOL than patients with other chronic conditions. Addressing mental health should be an integral part of outpatient HIV care.
Source: AIDS - Category: Infectious Diseases Tags: Epidemiology and Social Source Type: research
Conclusions Meta-analysis showed no association between T2DM prevalence and HIV infection or antiretroviral therapy; however, these results are limited by the high heterogeneity of the included studies and moderate-to-high risk of bias, as well as, the small number of studies included. There is a need for well-designed prospective longitudinal studies with larger population sizes to better assess incidence and prevalence of T2DM in African patients with HIV. Furthermore, screening for T2DM using gold standard methods in this population is necessary. Trial registration number PROSPERO42016038689.
Source: BMJ Open - Category: Journals (General) Authors: Tags: Open access, Epidemiology, Public health, HIV AIDS, Diabetes and Endocrinology Research Source Type: research
More News: Antidoxidants | Calcium | Diabetes | Diabetes Type 1 | Diabetes Type 2 | Drugs & Pharmacology | Endocrinology | Estradiol | Fortamet | HIV AIDS | Hormones | Insulin | Melatonin | Metformin | Omega 3 | Phosphorus | Study