Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system.

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system. Am J Physiol Endocrinol Metab. 2019 Nov 12;: Authors: Maurer SF, Fromme T, Mocek S, Zimmermann A, Klingenspor M Abstract Uncoupling protein 1 provides non-shivering thermogenesis fueled by the dissipation of energy from macronutrients in brown and brite adipocytes. The availability of thermogenic fuels is facilitated by the uptake of extracellular glucose. This conjunction renders thermogenic adipocytes in brown and white adipose tissue a potential target against obesity and glucose intolerance. We employed wildtype and uncoupling protein 1-ablated mice to elucidate this relationship. In three experiments of similar setup, uncoupling protein 1-ablated mice fed a high‑fat diet had either reduced or similar body mass gain, food intake and metabolic efficiency compared to wildtype mice, challenging the hypothesized role of this protein in the development of diet-induced obesity. Despite the absence of increased body mass, oral glucose tolerance was robustly impaired in uncoupling protein 1-ablated mice in response to high-fat diet. Postprandial glucose uptake was attenuated in brown adipose tissue but enhanced in subcutaneous white adipose tissue of uncoupling protein 1-ablated mice. These differences were explainable by expression of the insulin-responsive member 4 of the facilitated glucose transporter family and f...
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research