The Utility of Subcutaneous Methotrexate for Chronic Plaque Psoriasis in a Real-World Setting.

The Utility of Subcutaneous Methotrexate for Chronic Plaque Psoriasis in a Real-World Setting. Br J Dermatol. 2019 Nov 12;: Authors: Hollywood A, O'Keeffe C, Boggs J, Feighery C, Collins S Abstract The advent of biologic agents that target cytokines central to the psoriatic disease cascade have revolutionised the treatment of moderate to severe psoriasis. Methotrexate (MTX) remains the recommended first-line conventional systemic treatment for moderate to severe psoriasis.1 This is due to its well established efficacy, safety profile and low cost1 . Across published data, MTX demonstrates a PASI 75 of approximately 40% at weeks 12-162 , with a median drug survival of 1.8 years.3 The cost of oral MTX is less than 1%, and subcutaneous (SC) MTX less than 10% of that of the cheapest biologic agent in the Republic of Ireland. Oral MTX may be limited by its toxicity and drug survival.3. PMID: 31715016 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Authors: Carli L, Calabresi E, Governato G, Braun J Abstract Spondyloarthritis (SpA) is the umbrella term for a broad spectrum of inflammatory rheumatic diseases with typical but also rather different clinical manifestations, limited laboratory abnormalities and characteristic imaging features. For classification purposes, a so-called non-radiographic form (nr-axSpA) is differentiated from a radiographic one (r-axSpA) which is almost identical to the classical ankylosing spondylitis (AS) that is genetically strongly associated with the major histocompatibility complex class 1 antigen HLA-B27. In axSpA, the axial sk...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
This study does not go into detail about the extent to which these comorbidities may influence the increased risk of cancer in psoriasis patients. People with severe psoriasis often do not get enough relief with topical therapies (ones applied to the skin), such as topical corticosteroids and vitamin D analogues. They may then be started on medications that target specific immune cells and proteins. Some of these medications increase the risk of infections. Previous studies have found little to no increased risk of cancer in patients receiving these therapies. Other treatments, such as phototherapy (light therapy), are kno...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Skin and Hair Care Source Type: blogs
Abstract Itching, or pruritus, can be defined as an unpleasant sensation that evokes the desire to scratch. Pruritus is most commonly associated with a primary skin disorder such as atopic dermatitis (AD), psoriasis, etc., and can have a major impact on the quality of life of those patients. Itch-induced scratching can further damage the skin barrier, leading to a worsening of symptoms. For that reason, it is important to manage pruritus. Topical glucocorticoids are commonly the first-line therapy in the management of AD and psoriasis patients. We found that topical glucocorticoids induce pruritus in mice under ce...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
It was on November 21st that I was last in Copenhagen, not to have some of that famous Æbleflæsk but to moderate an OECD event. I was tasked to challenge health ministers and other policy makers about the impact of advanced technologies on patients’ lives and what regulations would facilitate these changes. It was encouraging to see country leaders take a positive stance towards digital health and to hear about concrete examples as to how they are implementing technology to modify their local healthcare landscape. This experience served as an inspiration to write this article. In it we will highli...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Policy digital health Medicine technology healthcare design Source Type: blogs
We report on a patient with severe psoriasis vulgaris who developed drug-induced interstitial lung disease (DILD) during treatment with ustekinumab. The diagnosis was based on coincidence with start of therapy, high-resolution computer tomography of the thorax and bronchoalveolar lavage. After discontinuation of the treatment with ustekinumab the clinical symptoms and the chest scan results improved. This case highlights a possible adverse event of ustekinumab. PMID: 31792580 [PubMed - as supplied by publisher]
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
Publication date: Available online 28 November 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Sonia S. Pandey, Furqan A. Maulvi, Priya S. Patel, Manish R. Shukla, Kinjal M. Shah, Arti R. Gupta, Shrikant V. Joshi, Dinesh O. ShahAbstractPsoriasis is a widespread chronic disease affecting 1-3% of total population. In major cases (>80%), it is treated by topical application of corticosteroids. However, the topical route is very challenging due to physico-chemical nature of diseased stratum corneum and so no single treatment works for every patient. The oral route showed severe side effects due to systemic immu...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Deep-immunophenotyping of the circulatory T cell compartment using mass cytometry and unsupervised clustering analysis, identifies phenotypic and functional differences in patients with atopic dermatitis (AD) and psoriasis, highlighting the stronger systemic component associated with AD.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
(Wiley) An analysis published in the Journal of the European Academy of Dermatology and Venereology revealed considerable sex differences when considering links between psoriasis and metabolic disorders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Contributors : Jichao Deng ; Zhanjun LiSeries Type : Expression profiling by high throughput sequencingOrganism : Oryctolagus cuniculusPRSS53, a member of the membrane-anchored serine proteases, hydrolyzes peptide bonds and is highly expressed in the hair follicle IRS, medulla, precortex and some melanocytes1. Previous studies reported that Prss53 is a psoriasis susceptibility locus and is linked to systemic lupus erythematosus, suggesting its potential roles in skin function2. The Q30R SNP in Prss53 may influence hair shape and is involved in the human variation of head hair shape among different continental groups1. In a...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Oryctolagus cuniculus Source Type: research
Psoriasis is a chronic, immune-mediated disorder with chronic plaque psoriasis being the primary manifestation during the remission stage. Patients often have a slow course and long history of the disease. The...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
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