Critical review on proteotypic peptide marker tracing for six allergenic ingredients in incurred foods by mass spectrometry

Publication date: Available online 13 November 2019Source: Food Research InternationalAuthor(s): Rosa Pilolli, Chiara Nitride, Nathalie Gillard, Anne- Catherine Huet, Christof van Poucke, Marc de Loose, Olivier Tranquet, Collette Larré, Karine Adel-Patient, Hervé Bernard, E.N. Clare Mills, Linda MonaciAbstractPeptide marker identification is one of the most important steps in the development of a mass spectrometry (MS) based method for allergen detection, since the robustness and sensitivity of the overall analytical method will strictly depend on the reliability of the proteotypic peptides tracing for each allergen. The European legislation in place issues the mandatory labelling of fourteen allergenic ingredients whenever used in different food formulations. Among these, six allergenic ingredients, namely milk, egg, peanut, soybean, hazelnut and almond, can be prioritized in light of their higher occurrence in food recalls for undeclared presence with serious risk decision.In this work, we described the results of a comprehensive evaluation of the current literature on MS-based allergen detection aiming at collecting all available information about proteins and peptide markers validated in independent studies for the six allergenic ingredients of interest. The main features of the targeted proteins were commented reviewing all details available about known isoforms and sequence homology particularly in plant-derived allergens. Several critical aspects affectin...
Source: Food Research International - Category: Food Science Source Type: research

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Publication date: December 2019Source: British Journal of Oral and Maxillofacial Surgery, Volume 57, Issue 10Author(s): Martin Dodd, Anne Begley
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Conditions:   HIV/AIDS;   HIV Prevention Intervention:   Drug: Tenofovir Douche Sponsors:   Johns Hopkins University;   National Institute of Allergy and Infectious Diseases (NIAID);   CONRAD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSIONS: SMC is a multi-caused symptom. They are associated with lower memory performance, but also with variables related to health, social aspects and lifestyle. When faced with a patient with SMC, which may be due to cognitive impairment because of Alzheimer's disease, these associations should be taken into account to assess this risk and know when follow-up is most needed. PMID: 31820817 [PubMed - in process]
Source: Revista de Neurologia - Category: Neurology Authors: Tags: Rev Neurol Source Type: research
This study estimated healthcare costs and utilisation for patients with AR and asthma. Mean annual outpatient visits, pharmaceutical costs and inpatient hospitalisations were calculated for 2010 and 2014, with pharmaceutical and inpatient costs stratified by AIT use. AR and asthma patients had a 35% higher mean number of physician visits and up to 90% higher mean pharmaceutical costs compared to controls. The cost of pharmaceuticals and inpatient hospitalisations were 54% lower in those prescribed AIT. Further research is recommended to understand the reasons for these cost differences. PMID: 31818082 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention News Source Type: news
Although most summer camps welcome kids with food allergies, they often don't ask these campers to provide individualized emergency plans as a requirement for attendance, a U.S. study suggests.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news
AbstractMast cells (MCs) are portions of the innate and adaptive immune system derived from bone marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype, and function are determined by their microenvironment. MCs accumulate at inflammatory sites associated with atopy, wound healing, and malignancies. They interact with the external environment and are predominantly located in close proximity of blood vessels and sensory nerves. MCs are key initiators and modulators of allergic, anaphylactic, and other inflammatory reactions, by induction of vasodilation, promoting of vascular permeability, r...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
New England Journal of Medicine,Volume 381, Issue 24, Page 2338-2351, December 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
Epidemiological studies report that overweight or obese asthmatic subjects have more severe disease than those of a healthy weight. We postulated that accumulation of adipose tissue within the airway wall may occur in overweight patients and contribute to airway pathology. Our aim was to determine the relationship between adipose tissue within the airway wall and body mass index (BMI) in individuals with and without asthma. Transverse airway sections were sampled in a stratified manner from post mortem lungs of control subjects (n=15) and cases of nonfatal (n=21) and fatal (n=16) asthma. The relationship between airway adi...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking, Asthma and allergy Original Articles: Asthma and COPD Source Type: research
ková Anna Podlasek When the landfill use comes to end, important subsequent steps include aftercare, safety assurance, and ecological regeneration. Landfill revegetation is cost-effective and eco-friendly approach in the management of landfill areas, which serves the purpose of stabilization and provides a pleasant landscape. There are various vegetation types that can be planted, yet grass species are often used for low-cost reasons. Plants can be important sources of air pollution, particularly by grass pollen. The main goal of our study was to identify plant species that produce allergenic pollen. Long-term...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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