Metabolic profile of pitaya (Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose) by UPLC-QTOF-MSE and assessment of its toxicity and anxiolytic-like effect in adult zebrafish

Publication date: January 2020Source: Food Research International, Volume 127Author(s): Sandra Machado Lira, Ana Paula Dionísio, Marcelo Oliveira Holanda, Chayane Gomes Marques, Gisele Silvestre da Silva, Lia Coêlho Correa, Glauber Batista Moreira Santos, Fernando Antonio Pinto de Abreu, Francisco Ernani Alves Magalhães, Emanuela de Lima Rebouças, Jhonyson Arruda Carvalho Guedes, Danielle Ferreira de Oliveira, Maria Izabel Florindo Guedes, Guilherme Julião ZocoloAbstractPitaya is a Cactacea with potential for economic exploitation, due to its high commercial value and its functional components – such betalains, oligosaccharides and phenolic compounds. Although the biological activities of pitaya have been studied using in vivo and in vitro models (anti-inflammatory and antiproliferative activities, as example), its anxiolytic-like effect is still unexplored. Therefore, the aim of this work was to perform a characterization of pulp and peel of pitaya (Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose) using UPLC-QTOF-MSE, and to assess its toxicity and anxiolytic-like effect in adult zebrafish (Danio rerio). The results showed 16 and 15 compounds (in pulp and peel, respectively), including maltotriose, quercetin-3-O-hexoside, and betalains, putatively identified by UPLC-QTOF-MSE. Thus, pitaya pulp and peel showed no toxicity in both models tested (Vero cell lines and zebrafish model, LC50 ˃ 1 mg/mL); and a significant anxiolytic activity, since the treated fish...
Source: Food Research International - Category: Food Science Source Type: research