Efficacy of sarolaner on the treatment of myiasis caused by Cochliomyia hominivorax (Diptera: Calliphoridae) in dogs

Publication date: Available online 12 November 2019Source: Veterinary ParasitologyAuthor(s): Priscila Cardim de Oliveira, Gabriela Pereira Salça de Almeida, Jaime Dias Cardoso, Renan Bernardes Tavares, Júlio Israel Fernandes, Thaís Ribeiro Correia Azevedo, Guilherme Gomes Verocai, Fabio Barbour ScottABSTRACTThe aim of this study was to evaluate the larval expulsion, larvicidal effect and overall efficacy of sarolaner on the treatment of myiasis caused by New World screwworm Cochliomyia hominivorax in naturally infested dogs. Eight Beagle dogs received a single dose of saroalner 40 mg, with dosage ranging from 2.7 mg/kg to 3.7 mg/kg. Evaluations occurred every 15 minutes in the first hour, every hour for up to 6 hours, and after 24 hours of treatment. At 24 hours post-treatment, total wound cleaning was performed, including removal and counting of remaining live and dead larvae. The animals received antibiotic, analgesic and wound cleaning support until complete wound healingThe average expulsion of the larvae was 50.9% occurring mainly after 4 hours of treatment. The larvicidal effect was 70.6% at 6 hours after treatment and 100% at 24 hours. The mean retention rate of dead larvae of sarolaner was 33.9%, The overall efficacy was 100%, thus making sarolaner an excellent treatment option in myiasis caused by C. hominivorax larvae in dogs.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research