Surface area- and mass-based comparison of fine and ultrafine nickel oxide lung toxicity and augmentation of allergic response in an ovalbumin asthma model.
Conclusions: Collectively, these findings suggest that although NiO surface area correlates best with acute pulmonary injury and inflammation following respiratory exposure, other physico-chemical properties may contribute to the modulation of immune responses in the lung. PMID: 31707870 [PubMed - as supplied by publisher]
Conclusions: Variation in the NAT1 gene modifies asthma risk in children exposed to secondhand-smoke. To our knowledge, this is the first report of a gene-environment interaction between NAT1 variants, smoke exposure, cotinine levels, and pediatric asthma. NAT1 genotype may have clinical utility as a biomarker of increased asthma risk in children exposed to smoke. PMID: 31809667 [PubMed - as supplied by publisher]
We examined our primary care birth cohort of 158,510 pediatric patients, of whom 214 patients met 2017 FPIES diagnostic criteria. We measured the influence of FPIES on developing subsequent atopic disease.ResultsPediatric FPIES incidence was between 0.17% and 0.42% depending on birth year. As in prior reports, most patients had an acute presentation (78%), and milk, soy, oat, rice, potato, and egg were common triggers. The mean age of diagnosis was 6.8 months. Atopic comorbidity was higher in patients with FPIES compared with healthy children (AD, 20.6% vs 11.7%; IgE-FA, 23.8% vs 4.0%; asthma, 26.6% vs 18.4%; AR, 28.0% vs 16.7%; P
Mycobacterium chelonae is a rare acid fast bacilli that grows rapidly when compared to other members of the Mycobacteria genus. Localized cutaneous infections (i.e. cellulitis/ abscess) are common in immunocompetent patients, but in an immune compromised host disseminated infections are more prevalent. Disseminated cutaneous manifestations most commonly present in patients who are immunosuppressed by malignancy, corticosteroid therapy, various immunomodulating drugs used in organ transplantation or secondary immunodeficiencies1.
(Natural News) Breastfeeding your baby can be a difficult task, but your hard work will surely pay off. Exclusively breastfeeding your child for the first three months can lower his or her risk of suffering from eczema later in life, according to a study presented in the American Academy of Allergy, Asthma &Immunology 2019...
Conditions: Allergy; Asthma; Food Allergy; Allergic Sensitisation; Atopic Dermatitis Intervention: Sponsors: Pontificia Universidad Catolica de Chile; University of Chile; Comisión Nacional de Investigación Científica y Tecnológica Recruiting
Doctors on Long Island say two migrant children showed up at their hospital in seriously ill condition at least in part because their asthma medication had been taken away by immigration authorities at the southern border.Reuters Health Information
Authors: Saenza De San Pedro A, Lopes MP, Sokolova A, Abreu C, Lopes C Abstract Summary: Atopic Dermatitis (AD) affects both children and adults and is a serious health concern in many countries. AD is a complex disease with host and environmental factors underlying its pathology. Its treatment is multidimensional reflecting the diverse nature of its triggers and includes emollients, topical steroids and calcineurin inhibitors among others. Immunological dysfunction can be addressed broadly with systemic immunosupressors and specifically with monoclonal antibodies. Dupilumab, which targets IL-4 and IL-13 was grante...
(American College of Allergy, Asthma, and Immunology) A new article in Annals of Allergy, Asthma and Immunology shows a significant association between multiple prenatal and early life exposures to indoor pollutants and the degree of allergic sensitivity in 2-year-olds.