Exhaled TGF- β1 levels before and after an exercise challenge in asthmatic and healthy children, and during exacerbation.

Exhaled TGF-β1 levels before and after an exercise challenge in asthmatic and healthy children, and during exacerbation. J Asthma. 2019 Nov 11;:1-10 Authors: Keskin O, Ozkars MY, Gogebakan B, Kucukosmanoglu E, Keskin M, Bayram H Abstract Background: There is conflicting data regarding the role of transforming growth factor-β1 (TGF-β1) in the pathogenesis of airway hyper-reactivity and asthma exacerbation.Objective: To investigate the role of exhaled-TGF-β1 in exercise-induced bronchospasm (EIB) in asthmatic and nonasthmatic healthy children, and in asthma exacerbation and asthma control.Methods: The exhaled-TGF-β1 levels of 56 stable asthmatic children and 15 nonasthmatic healthy children were evaluated before and 30 min after an exercise challenge. The exhaled-TGF-β1 levels of 20 additional children with asthma exacerbation were evaluated.Results: While no significant difference in the exhaled-TGF-β1 levels was found at the baseline, exhaled-TGF-β1 levels after the exercise challenge were significantly higher in the non-EIB (n = 31) asthmatics when compared to the asthmatic children with EIB (n = 25) (p = 0.04). Although there was a statistically significant increase in the concentration of the exhaled-TGF-β1 after the exercise challenge in the non-EIB asthmatics (p = 0.008), the concentration of the TGF-β1 was not increased after the exercise...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research

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The editors and staff of the Annals of Allergy, Asthma and Immunology would like to thank the flowing individuals who gave of their time to provide reviews of submitted manuscripts between January 1 and June 30, 2019. The high-quality manuscript reviews provided by these individuals is essentially to the peer review process so necessary for a journal like ours to provide scientifically sound as well as interesting and engaging articles for our readers. Thanks to each of you for your service.
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Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
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