Medullary thyroid cancer: an introduction.
Medullary thyroid cancer: an introduction. Curr Oncol. 2019 Oct;26(5):294 Authors: Gupta MK PMID: 31708647 [PubMed - in process]
Nature Reviews Endocrinology, Published online: 09 December 2019; doi:10.1038/s41574-019-0307-2Multikinase inhibitors are effective treatments for thyroid cancers, acting primarily as antiangiogenic agents. This year, advances have been made in selective targeting of RET and BRAF in patients with medullary and anaplastic thyroid cancers, respectively. However, Hürthle cell carcinomas have a unique genomic landscape with no dominant truncal drivers, precluding simplistic approaches to therapeutic targeting.
ConclusionThis study suggested that the C allele of XRCC1 had an 18% significantly decreased risk of TC in Chinese, and there were no significant associations among Caucasians under all genetic models.
We report FDG PET/CT images of a 63-year-old woman referred for characterization of osteolytic lesions of the cervical spine. This patient with chronic renal failure had a history of follicular thyroid carcinoma with undifferentiated cells, treated by a total thyroidectomy, completed by radioactive iodine in 2017. Because of cancer history, a FDG PET/CT was performed and showed multiple moderately hypermetabolic osteolytic lesions of the spine from C3 to T1, with joint erosion on CT. A laminectomy was performed for cervical spinal cord decompression and revealed a gouty tophus.
ConclusionsThe paucity of studies about GPER1 in the thyroid, as well as methodological differences between them, precludes firm conclusions about GPER1 role in the thyroid, although there are some evidences of GPER1-induced proliferation of thyroid cancer cells.Graphical abstract
Thyroid, Ahead of Print.
Publication date: Available online 6 December 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Giacomo Lettini, Michele Pietrafesa, Silvia Lepore, Francesca Maddalena, Fabiana Crispo, Alessandro Sgambato, Franca Esposito, Matteo LandriscinaAbstractThyroid cancer is the most common endocrine malignancy, with well-differentiated subtypes characterized by an excellent prognosis due to their optimal sensitivity to standard therapies whereas poorly differentiated and anaplastic tumours by chemo/radio-resistance and unfavourable outcome. Heat Shock Proteins (HSPs) are molecular chaperones overexpressed in thyroid malig...
CONCLUSIONS: DNA methylation levels of three markers can be useful for differentiating differentiated thyroid cancer from non-malignant follicular thyroid lesions, and may serve as prognostic biomarkers for predicting recurrent or persistent disease following surgery for differentiated thyroid cancer. PMID: 31797753 [PubMed - as supplied by publisher]
The objective of the current study was to determine if the development of thyroid cancer is associated with a differential survival in radiation-exposed individuals. METHODS: We conducted a matched prospective cohort mortality follow-up study based on data from a cohort of 4296 individuals who were irradiated for enlarged tonsils during their childhood (between 1939 and 1962) and were prospectively followed since 1974. The study matched an irradiated subject who developed (was exposed to) thyroid cancer (a "case") and two irradiated subjects, who had not developed (were not exposed to) thyroid cancer ("c...
Thyroid, Ahead of Print.
AbstractIn patients with thyroid fine-needle aspiration (FNA) report of suspicious for malignancy (SFM), both lobectomy and thyroidectomy might be considered. BRAF mutation analysis could guide towards accurate surgical therapy. The primary outcome was the reliability of BRAF (V600E) in detecting malignancy in nodules with FNA reading of SFM. The secondary outcome was to analyze its positive predictive value (PPV) and negative predictive value (NPV) considering the surgical histology as gold standard. A literature search of online databases was performed in June 2019. BRAF prevalence among thyroid nodules with FNA read as ...