Multi-View Graph Convolutional Network and Its Applications on Neuroimage Analysis for Parkinson's Disease.

Multi-View Graph Convolutional Network and Its Applications on Neuroimage Analysis for Parkinson's Disease. AMIA Annu Symp Proc. 2018;2018:1147-1156 Authors: Zhang X, He L, Chen K, Luo Y, Zhou J, Wang F Abstract Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive or disease progression modeling of PD using clinical and biomarkers data. Neuroimaging, as another important information source for neurodegenerative disease, has also arisen considerable interests from the PD community. In this paper, we propose a deep learning method based on Graph Convolutional Networks (GCN) for fusing multiple modalities of brain images in relationship prediction which is useful for distinguishing PD cases from controls. On Parkinson's Progression Markers Initiative (PPMI) cohort, our approach achieved 0.9537±0.0587 AUC, compared with 0.6443±0.0223 AUC achieved by traditional approaches such as PCA. PMID: 30815157 [PubMed - indexed for MEDLINE]
Source: AMIA Annual Symposium Proceedings - Category: Bioinformatics Tags: AMIA Annu Symp Proc Source Type: research

Related Links:

Early diagnosis of Parkinson's diseases (PD) is challenging; applying machine learning (ML) models to gait characteristics may support the classification process. Comparing performance of ML models used in various studies can be problematic due to differen...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Publication date: January 2020Source: The Lancet Neurology, Volume 19, Issue 1Author(s): The Lancet Neurology
Source: The Lancet Neurology - Category: Neurology Source Type: research
Condition:   Parkinson Disease Intervention:   Other: Home titration Sponsors:   Rigshospitalet, Denmark;   AbbVie Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Co-founded by World-Renowned Stem Cell Scientist Jeanne F. Loring, Ph.D. and Andres Bratt-Leal, Ph.D. Led by Chief Executive Officer Howard Federoff, M.D., Ph.D., Former Vice Chancellor for Health Affairs and Chief Executive Officer of the University of... Regenerative Medicine, Neurology, Venture Capital Aspen Neuroscience, cell therapy, Parkinson's disease
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
CONCLUSIONS: despite increasing evidence that tDCS may improve motor symptoms, the results showed that fully optimized tDCS protocols are not yet established. PMID: 31821532 [PubMed - in process]
Source: Archives Italiennes de Biologie - Category: Neuroscience Tags: Arch Ital Biol Source Type: research
CONCLUSION: The results suggest that the efficiency of applied cognitive strategy behaviours is compromised in a certain pattern in people with Parkinson's disease, and that it declines with disease progression. PMID: 31820814 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Current medications for neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), and Schizophrenia mainly target disease symptoms. Thus, there is an urgent need to develop novel therapeutics that can delay, halt or reverse disease progression. AD, HD, PD, and schizophrenia are characterized by elevated oxidative and nitrosative stress, which play a central role in pathogenesis. Clinical trials utilizing antioxidants to counter disease progression have largely been unsuccessful. Most antioxidants are relatively non-specific and do not adequately t...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
New research in mice and flies suggests that failure to transport molecules that break down proteins in neurons may lead to neurodegenerative diseases.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news
New research in mice and flies suggests that failure to transport molecules that break down proteins in neurons may lead to neurodegenerative diseases.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Condition:   Parkinson Disease Intervention:   Other: Non pharmacological therapy Sponsor:   Puerta de Hierro University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Bioinformatics | Brain | Learning | Neurology | Parkinson's Disease | Study | Universities & Medical Training