Are pretomanid-containing regimens for tuberculosis a victory or a victory narrative?

Publication date: Available online 12 November 2019Source: The Lancet Respiratory MedicineAuthor(s): Lindsay McKenna, Jennifer Furin
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research

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A 32-year-old white woman was referred for evaluation of palate lesion with 3 months ’ duration. Medical history included recent investigation for tuberculosis due to the presence of nodules detected on chest radiograph and previous treatment for syphilis. The patient exam revealed nasal obstruction, cough, secretion drainage, and weight loss. Extraoral examination showed erythema and edema in the face. Moreover, erosive lesions, crusts and purulent drainage were observed in the nasal area. Intraorally, an extensive necrotic lesion with bone destruction and exposure, midline palatal perforation was detected.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This reports a case of a 46-year-old female patient complaining of weakness, dysphagia, and a tongue lesion. She had history of human immunodeficiency virus (HIV) positivity, noncompliance with antiretroviral therapy, and pulmonary tuberculosis.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
This study exemplifies the case of a 57-year-old white man, a bookseller, smoker, and resident in an area without basic sanitation, who had white plaques mixed with erythematous areas in oropharynx with a 5-month evolution, difficulty in swallowing, and episodes of night fever.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Immunosuppression is defined as the reduction of activity or efficiency of the immune system. Neutropenia is the decrease in the number of neutrophils, which can cause ulcers in the oral cavity. The first patient, a 32-year-old HIV-positive patient with tuberculosis, presented ulcers on the upper and lower labial mucosa, bilateral buccal mucosa, and tongue. The second, a 47-year-old HIV-positive patient, had ulcers on the tongue and buccal mucosa. The third, a 17-year-old patient with osteosarcoma of the femur, metastasis in lung, lymph nodes, and tibia who is undergoing chemotherapy, had ulcers on bilateral buccal mucosa.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Paracoccidioidomycosis (PCM) is a systemic mycosis whose etiologic agent is the thermodimorphic fungus of the genus Paracoccidioides. Differential diagnosis may include oral squamous cell carcinoma (SCC), tuberculosis, histoplasmosis, and Wegener granulomatosis. A 45-year-old male patient was attended in an oral medicine service with complaint of "infection of the tongue." Intraoral examination found deep ulcer of granulomatous bed with raised edges and hard palpation in the lateral tongue and mouth floor with 2 months of evolution.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In this study, we have synthesized four heterocyclic azo dyes by conventional diazo-coupling reaction between aniline derivatives with 5-methyl-2-(6-methyl-1,3-benzothiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one at lower temperatures and are characterized by physico-chemical techniques. The quantum chemical study was also employed to understand the chemical reactivity of the compounds by using B3LYP method in conjunction with 6–31G (d, p) basis set. The photochemical property of the dyes was studied and they showed higher intensity and good quantum yield with respect to the Rhodamine B. The azo dyes were screened for the...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 13 December 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Valnês S. Rodrigues-Junior, Anne D. Villela, Bruno L. Abbadi, Nathalia D.M. Sperotto, Kenia Pissinate, Jaqueline N. Picada, Juliana Bondan da Silva, Cristiano V. Bizarro, Pablo Machado, Luiz A. BassoAbstractNew effective compounds to treat tuberculosis are urgently needed. IQG-607 is an orally active anti-tuberculosis drug candidate, with promising preliminary safety profile and anti-mycobacterial activity in both in vitro and in vivo models of tuberculosis infection. Here, we evaluated the mutagenic and genoto...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
Authors: Twumasi C, Asiedu L, Nortey ENN Abstract Several mathematical and standard epidemiological models have been proposed in studying infectious disease dynamics. These models help to understand the spread of disease infections. However, most of these models are not able to estimate other relevant disease metrics such as probability of first infection and recovery as well as the expected time to infection and recovery for both susceptible and infected individuals. That is, most of the standard epidemiological models used in estimating transition probabilities (TPs) are not able to generalize the transition esti...
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
Publication date: Available online 14 December 2019Source: Journal of Structural BiologyAuthor(s): Nina T. Odermatt, Moreno Lelli, Torsten Herrmann, Luciano A. Abriata, Aleksandre Japaridze, Hubert Voilquin, Rajkumar Singh, Jérémie Piton, Lyndon Emsley, Giovanni Dietler, Stewart T. ColeAbstractIn bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to Actinobacteria and essential for survival of the human pathog...
Source: Journal of Structural Biology - Category: Biology Source Type: research
Authors: Abad CL, Razonable RR Abstract INTRODUCTION: Tuberculosis (TB) in solid organ transplant (SOT) recipients is associated with significant morbidity and mortality. Its management in transplant recipients is difficult and highly complex, given the underlying immunosuppression and the risks of drug-drug interactions imposed by immunosuppressive drugs that are needed to maintain the transplant allograft.Areas covered: We provide a brief review of TB in SOT, and discuss the clinical indications, mechanisms of action and drug resistance, drug-drug interactions, and adverse effects of anti-TB drugs. We provide a s...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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