Clinical Trail to Evaluate the Efficacy and Safety of DWJ1451
Condition: Hypertension, Dyslipidemia Interventions: Drug: Amlodipine/Olmesartan 10/40mg (Combination drug), Ezetimibe/Rosuvastatin 10/20mg(Combination drug); Drug: Olmesartan 40mg, Ezetimibe/Rosuvastatin 10/20mg(Combination drug); Drug: Amlodipine/Olmesartan 10/40mg (Combination drug) Sponsor: Daewoong Pharmaceutical Co. LTD. Recruiting
ConclusionsComputational measures reflecting individual PVS size, length and width were more strongly associated with WMH, stroke and hypertension than computational count or visual PVS score. Multidimensional computational PVS metrics may increase sensitivity to detect associations of PVS with risk exposures, brain lesions and neurological disease, provide greater anatomic detail and accelerate sunderstanding of disorders of brain fluid and waste clearance.Graphical abstract
ConclusionElderly patients who had hip fracture surgery and developed wound infections had an increased LOS. However social issues also contributed to the increase length of stay that could be addressed by proper planning and involvement of families and care givers. The factors identified could be used as a starting point for planning services aimed at decreasing the hospital stay of elderly patients.
ConclusionsThe data regarding ketamine use in mechanically ventilated patients is limited in terms of quantity, methodological quality, and demonstrated clinical benefit. Ketamine may play a role as a sedative-sparing agent, but may be associated with harm. High-quality studies are needed before widespread adoption of ketamine earlier in the sedation pathway.
ConclusionThis study indicates that the antihypertensive activity of P. niruri extract is mediated by vasoactive phytoconstituents that dilate the arterial wall via endothelium-dependent pathways and β-adrenoceptor activity which, in turn, cause vasorelaxation and reduce blood pressure.Graphical abstract
Publication date: Available online 5 November 2019Source: Indian Heart JournalAuthor(s): Sreenivas Reddy, Suraj Kumar, Jeet Ram Kashyap, Raghavendra Rao, Vikas Kadiyala, Hithesh Reddy, Naindeep Kaur, Vadivelu Ramalingam, Jaspreet KaurAbstractObjectiveThe coronary artery dimensions have important diagnostic and therapeutic implications in management of coronary artery disease (CAD). There is paucity of data on the coronary artery size in the Indian population as measured by intravascular ultrasound (IVUS).MethodsA total of 303 patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) wi...
Condition: Hypertension, Pulmonary Interventions: Other: Blood Sample; Device: ReCIVA® Breath Sampler and CASPER air supply unit Sponsor: Janssen Research & Development, LLC Not yet recruiting
This study analyzed whether calpain-1 causes cardiac hypertrophy and dysfunction by modulating the expression and activity of MMP-2 in renovascular hypertension.Main methodsMale Wistar rats were submitted to two kidneys, one clip (2K1C) model of hypertension or sham surgery and were treated with verapamil (VRP, 8 mg/kg/bid) by gavage from the second to tenth week post-surgery. Systolic blood pressure (SBP) was weekly assessed by tail-cuff plethysmography and morphological and functional parameters of LV were analyzed by echocardiography. MMP-2 activity was analyzed by in situ and gelatin zymography, while calpain-1 activ...
Conclusion/Clinical Relevance: The case demonstrated that refractory AD could be managed with ITB in an emergency. PMID: 31815605 [PubMed - as supplied by publisher]
Genetic Testing and Molecular Biomarkers, Ahead of Print.
ConclusionsThe most common haemodynamic profile observed in adults with SD consisted of hypochronotropism and hypervolaemia, with normal values for peripheral vascular resistance and optimal mean BP values. There were no participants with hypertension in our sample.ResumenObjetivosSi bien se desconocen los motivos, la prevalencia de hipertensión arterial y de eventos cardiovasculares ateroscleróticos en la población adulta con síndrome de Down (SD) es anecdótica. Para entender mejor este hallazgo evaluamos las características hemodinámicas de una cohorte de adultos con SD.M&...