Senescent Cells Mediate the Incidence of Periodontitis in Diabetic Patients

Insofar as either type 1 diabetes or type 2 diabetes increase the burden of senescent cells, we might say that the condition literally accelerates aging. The accumulation of lingering senescent cells is a contributing cause of aging; these errant cells disrupt tissue function and produce the characteristic profile of chronic inflammation known as inflammaging via a potent mix of secreted molecules and vesicles. Diabetic patients suffer more and worse gum disease, periodontitis, than their healthy peers, and researchers here show that hyperglycemia leads to increased numbers of senescent cells in gum tissue, causing all of the expected downstream consequences resulting from inflamed gums. Inflammaging was recently affiliated with the progression of diabetic complications. Local cellular senescence together with senescence-associated secretory phenotype (SASP) are the main contributors to inflammaging. However, little is known about their involvement in diabetic periodontitis. Gingiva is the first line of host defense in the periodontium, and macrophages are key SASP-carrying cells. Here, we explored the molecular mechanism by which hyperglycemia drives the inflammaging in the gingival tissue of diabetic mice and macrophages. We demonstrated that hyperglycemia increased the infiltrated macrophage senescence in gingival tissue of diabetic mice. Simultaneously, hyperglycemia elevated the local burden of senescent cells in gingival tissue and induced the serum secr...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs

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One of the more unexpected recent findings relating to cellular senescence is that it appears to be an important part of the mechanisms that lead to loss of the pancreatic β-cells responsible for insulin secretion in both type 1 diabetes and type 2 diabetes - which are very different conditions, despite the shared name. The authors of the brief open access commentary noted here discuss the present state of this research. Age is one of the major risk factors for the development of type 2 diabetes mellitus (T2D). However, the understanding of how cellular aging contributes to diabetes pathogenesis is incomplete...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionsContinued efforts to improve hypoglycemia evaluation, documentation, and management are needed, particularly in primary care. This includes not only screening at-risk patients for hypoglycemia, but also modifying their treatment regimens and/or leveraging DSMES.
Source: Endocrine - Category: Endocrinology Source Type: research
First approved for US adults in 2015, Toujeo (insulin glargine 300 units/mL injection) may now be used in children as young as 6 years with type 1 or type 2 diabetes.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Alert Source Type: news
First approved for US adults with type 1 and type 2 diabetes in 2015, Toujeo (insulin glargine 300 units/mL injection) may now be used in children as young as 6 years with type 1 diabetes.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Alert Source Type: news
This analysis evaluates the cost-effectiveness of insulin degludec (degludec) versus biosimilar insulin glargine U100 (glargine U100) in patients with type 1 (T1DM) and type 2 diabetes mellitus (T2DM) in Bulga...
Source: BMC Endocrine Disorders - Category: Endocrinology Authors: Tags: Research article Source Type: research
In conclusion, the present results revealed the following: Z+2 may serve as a protective factor for DR in Caucasian individuals and those with T1D; Z+4 may be a protective factor for DR in patients with T2D; Z-2 may represent a risk factor for DR in all subgroups analyzed; and Z-4 may be a risk factor for DR in Asian populations and patients with T2D. PMID: 31777552 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
This report focuses on the clinical features of these recipients with succ essful delivery of newborns at Tokyo Women’s Medical University approximately 40–50 years ago. Three of the recipients [type 2 diabetes,n  =  2 (cases 1 and 3); type 1 diabetes,n  =  1 (case 4)] were treated before, during and after pregnancy, whereas one patient with type 2 diabetes (case 2) was only treated during pregnancy. Even though three recipients had a past history of stillbirth due to insufficient control of diabetes, all four recipients were directed to try to main tain normoglycemia before and...
Source: Diabetology International - Category: Endocrinology Source Type: research
ConclusionThese results showed that SRD5A1 rs1691053 gene polymorphism was independently associated with glycometabolism. The interaction between a genetic polymorphism from SRD5A1 and testosterone involved glycometabolism was identified in males. Although this preliminary data should be replicated with other rigorous researches, it highlighted the importance of the SNP-testosterone interaction over the present of glycometabolism.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: December 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 8Author(s): Lisa D. Alexander, George Tomlinson, Denice S. FeigAbstractObjectiveOur aim in this study was to compare the effects of risk factors for large-for-gestational-age (LGA) birthweight between women with type 1 and type 2 diabetes mellitus (TIDM and T2DM, respectively).MethodsA retrospective cohort study was conducted for women with T1DM (n=152) and T2DM (n=255) attending a diabetes/pregnancy clinic during the period from 2009 to 2016. Multiple logistic regression analysis was used to identify variables associated with LGA birthwe...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
The incidence and prevalence of diabetes has rapidly increased worldwide in recent decades, mainly due to the rise in obesity and other risk factors for type 2 diabetes [T2D] [1]. There has been an associated global increase in the incidence and prevalence of diabetic kidney disease (DKD) — a frequent complication of long standing and poorly controlled diabetes [2–4]. The incidence of DKD among patients with type 1 diabetes [T1D] has been decreasing, probably due to substantial improvements in the management of DKD risk factors [2].
Source: Primary Care Diabetes - Category: Primary Care Authors: Source Type: research
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