Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling
ConclusionsPLS is associated with considerable subcortical grey matter degeneration and due to the extensive extra-motor involvement, it should no longer be regarded a pure upper motor neuron disorder. Given its unique pathological features and a clinical course which differs considerably from ALS, dedicated research studies and disease-specific therapeutic strategies are urgently required in PLS.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research