Surgical Fixation Using Screw-Rod Construct Instrumentation for Upper Cervical Instability in Pediatric Down Syndrome Patients
ConclusionsFixation for cervical instability is a critical component of the management of DS. A minority of patients receiving surgery were identified through asymptomatic screening. There was a high complication risk associated with surgery in our study; however, the addition of rigid fixation has lessened the complication rate compared with previous studies.Level of EvidenceLevel IV.
For over four decades, clinicians and researchers have suggested a relationship between congenital heart disease (CHD) and scoliosis, attributed to either the disease itself or to the long-term effects of cardiac surgery on the immature thoracic cage. However, no study has yet accounted for 22q11.2 deletion syndrome (22q11.2DS), the second most common cause of CHD after Down syndrome. 22q11.2DS has a scoliosis risk of 50%, but within 22q11.2DS a previous report found no significant association between scoliosis and CHD.
In this report, we described the anesthetic management of a 50-year-old woman with Down syndrome undergoing major cervical spine surgery. Components of the anesthetic that we thought would be difficult such as intravenous line placement and endotracheal intubation were accomplished without difficulty.
Journal of Clinical Sleep Medicine, Ahead of Print.
(Anglia Ruskin University) New research has discovered that Down's syndrome, Fragile X syndrome and Williams syndrome are all linked to sleep disruption in very young children, and that sleep plays a crucial role in the development of these children's language skills.
Conclusion: The lack, or inadequacy, of dental prostheses can impair the life quality of individuals in need of such restorations. Implant-supported dentures in combination with a bar construction improve the retention of prostheses in atrophied jaws. This form of restoration is also proving to be a successful therapy option for elderly persons with Down syndrome.
Conclusions and Implications: The developmentally progressive nature of the intervention and high dosage may have been instrumental in encouraging the onset of independent activation and earlier motor milestones.IMPLICATIONS FOR REHABILITATIONYoung children with Down syndrome were able to achieve independent activation in seated and standing modified ride-on cars.Developmentally progressive modified ride-on car interventions may facilitate motor skill development, but future work utilizing a randomized control group is needed to examine the potential motor developmental benefits of the STS model and power-push mode.The dev...
Condition: Down Syndrome Intervention: Other: Down Syndrome Clinic to You (DSC2U) Sponsors: Massachusetts General Hospital; Patient-Centered Outcomes Research Institute Completed
Genetics in Medicine, Published online: 13 January 2020; doi:10.1038/s41436-019-0718-4Assessment of laboratories offering cell-free (cf) DNA screening for Down syndrome: results of the 2018 College of American Pathology External Educational Exercises
To describe the mortality patterns, comorbidities, and attendance at accident and emergency departments among children with Down syndrome in Hong Kong.
Publication date: Available online 9 January 2020Source: American Heart JournalAuthor(s): SL Farr, SE Klewer, WN Nembhard, C Alter, KF Downing, JG Andrews, RT Collins, J Glidewell, A Benavides, A Goudie, T Riehle-Colarusso, L Overman, AP Riser, OsterAbstractBackgroundStudies of outcomes among adults with congenital heart defects (CHD) have focused on those receiving cardiac care, limiting generalizability. The Congenital Heart Survey To Recognize Outcomes, Needs, and well-beinG (CH STRONG) will assess comorbidities, healthcare utilization, quality of life, and social and educational outcomes, from a U.S. population-based s...