Ong term outcome of children born from mothers with autoimmune diseases

Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in the family planning. Pregnancies in these patients may carry several complications but nowadays the continue amelioration in treatment and management have greatly improved the pregnancy outcome. The main concern of these women obviously are the short- and long-term outcome of their children. A child born from a woman with autoimmune disease is potentially exposed in utero to maternal autoantibodies, cytokines and drugs and each item could impair his or her development. In addition, the maternal genetic heritage can favor autoimmunity. All these items could have a role, for example, in the development of autoimmune diseases (the same as the mother or different ones) or neurological disorders. Data in literature are controversial. This review will gather the available data possibly providing a useful tool for counselling the future mothers.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research