The recurring nightmare of my daughter's anorexia
Simon Brown lost his eldest child to the eating disorder - now he works with those who handled her care.
Condition: Anorexia Nervosa Interventions: Other: Physiotherapy Adapted Program; Diagnostic Test: Evaluation and Control Sponsor: Universidad de Murcia Recruiting
ConclusionThis phase II trial using pemetrexed/erlotinib in metastatic CRC with high EGFR expression met the primary endpoint of tumor response.Trial RegistrationThis study was registered at ClinicalTrials.gov (number NCT03086538).
Conclusion: This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. PMID: 31804778 [PubMed - as supplied by publisher]
DISCUSSION: Performers may be a particularly at-risk population for the development and/or maintenance for a range of eating disorders. PMID: 31800668 [PubMed - in process]
Anorexia nervosa (AN) is a severe psychological and potentially life-threatening eating disorder. The activity-based anorexia (ABA) mouse model is commonly used to investigate physiological abnormalities associated with this disorder. Characterizing the holistic biochemical alterations induced by anorexia is essential to understanding AN pathophysiology as well as to define biomarkers for prognosis.
Conditions: Anorexia Nervosa; Exercise Intervention: Other: Supervised strength training Sponsors: Mental Health Services in the Capital Region, Denmark; Department of Nutrition, Exercise and sports, University of Copenhagen; Department of Sports Science, Linnaeus University; Dep. of Sports, Physic. Educ. and Outdoor Studies, Uni. of South-Eastern Norway Not yet recruiting
This study aimed to determine the relationship between mindfulness, eating disorder symptomology and indicators of health in women with AN (n = 59) entering residential treatment. Participants completed a self-administered survey, including the Cognitive Affective Mindfulness Scale and other measures. Additional data from medical records were collected. Greater mindfulness was associated with less eating disorder symptoms (p = .049). This relationship was most profound in individuals with AN, including restrictive and binge-purge subtypes compared to individuals with atypical AN (interaction p-value = 0.044). Greater mindf...
Conclusion: This study shows that a specialized inpatient program for adolescents with severe EDs that was created using the principles of FBT results in positive short-term medical and psychological improvements as evidenced by improved weight gain and decreased markers of psychological distress.
AbstractPurpose of ReviewAppetitive behaviors are mediated through homeostatic and reward signaling of brain circuits. There has been increasing interest in the use of neuromodulation techniques aimed at targeting brain regions such as the lateral prefrontal and subcortical regions associated with dysregulation of eating behaviors.Recent FindingsInvasive brain stimulation techniques have demonstrated promising results in treating severe and enduring anorexia nervosa and morbid obesity. In addition, non-invasive techniques have been shown to successfully reduce food craving, hunger ratings, and calorie intake as well as bin...
Abstract Sex is a critical factor in the diagnosis and development of a number of mental health disorders including autism, schizophrenia, depression, anxiety, Parkinson's disease, multiple sclerosis, anorexia nervosa and others; likely due to differences in sex steroid hormones and genetics. Recent evidence suggests that sex can also influence the complexity and diversity of microbes that we harbour in our gut; and reciprocally that our gut microbes can directly and indirectly influence sex steroid hormones and central gene activation. There is a growing emphasis on the role of gastrointestinal microbiota in the ...