Primary Angiitis of the Central Nervous System Mimicking Glioblastoma: A Case Report and Literature Review

We described a case of PACNS initially misdiagnosed as glioblastoma. The patient was a 35 year-old female with right-sided weakness and expressive dysphasia. Brain MRI showed a tumor-like lesion highly suggestive of glioblastoma, therefor surgical removal was done. After a resection and an exhaustive workup, PACNS was ultimately diagnosed. The case illustrates a type of imaging presentation of PACNS that is often misdiagnosed as high-grade glioma. Differentiation between tumor-like PACNS lesions and actual CNS tumors is challenging due to similar MR images. To avoid unnecessary surgical interventions, we summarized previously reported mass-forming PACNS cases in adults from January 1, 2000, to December 31, 2018 and the imaging characteristics of PACNS. Some less commonly used diagnostic methods such as MR spectroscopy may also help clinicians distinguish PACNS from its mimics.
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Publication date: 10 December 2019Source: Cell Reports, Volume 29, Issue 11Author(s): Alice Buonfiglioli, Ibrahim E. Efe, Dilansu Guneykaya, Andranik Ivanov, Yimin Huang, Elisabeth Orlowski, Christina Krüger, Rudolf A. Deisz, Darko Markovic, Charlotte Flüh, Andrew G. Newman, Ulf C. Schneider, Dieter Beule, Susanne A. Wolf, Omar Dzaye, David H. Gutmann, Marcus Semtner, Helmut Kettenmann, Seija LehnardtSummaryMicroglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: Available online 19 October 2019Source: NeuroImage: ClinicalAuthor(s): Binke Yuan, Nan Zhang, Jing Yan, Jingliang Cheng, Junfeng Lu, Jinsong WuAbstractLanguage deficits following brain tumors should consider the dynamic interactions between different tumor growth kinetics and functional network reorganization. We measured the resting-state functional connectivity of 126 patients with left cerebral gliomas involving language network areas, including 77 patients with low-grade glioma (LGG) and 49 patients with high-grade glioma (HGG). Functional network mapping for language was performed by construction of ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Niels Hansen1,2* 1Department of Epileptology, University of Bonn Medical Center, Bonn, Germany2Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany Limbic encephalitis (LE) is an autoimmune disease defined by clinical criteria, such as seizures, psychiatric and in particular working memory abnormalities in conjunction with apparative criteria underlying structural or functional changes in the temporal lobe according to autoimmune encephalitis guidelines (1). Working memory encompasses a transient encoding of information in readiness for further processing within a time windo...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Primary intracranial LMS can rarely occur in immuno-competent adult patients and should be considered in the differential diagnosis of intraparenchymal lesions presenting with significant PTBE. PMID: 29279795 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
We describe a case of a patient with glioblastoma multiforme presenting as dominant temporal lobe epilepsy. Seizures were manifest as episodes of speech arrest on a background of long-standing history of episodic speech difficulty and headache. In this case, recognizing a change in semiology allowed diagnosis of a high-grade glioma. Use of electrocorticography during surgical excision of the tumor guided safe maximal excision without damage to eloquent cortex and helped confirm the diagnosis of brain tumor-related epilepsy.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
We describe a case of glioblastoma multiforme presenting as dominant temporal lobe epilepsy manifested as episodes of speech arrest on a background of long-standing history of episodic speech difficulty and headache. In this case, recognizing a change in semiology allowed diagnosis of a high-grade glioma. Use of electrocorticography during surgical excision of the tumor guided safe maximal excision without damage to eloquent cortex and helped confirm the diagnosis of tumor-related epilepsy.
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
Conclusions AF-tractography-integrated navigation is useful for glioma surgery near the language area, especially for patients with unsuitable conditions for awake craniotomy.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
The prognosis of patients with glioblastoma multiforme (GBM, WHO grade IV), the most common primary brain tumor in adults, is generally poor with median survival of less than one year in untreated patients and approximately 15 months following standard of care therapy. However, 10 % survival at 5 years was observed in a randomized phase III study. At GBM recurrence, the addition of bevacizumab (BEV), a humanized monoclonal antibody against circulating vascular endothelial growth factor (VEGF), resulted in a 3–4 month prolongation of progression-free survival (PFS) without improving overall survival (OS...
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: P08 Glioblastom and Anaplastic gliomas Source Type: research
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Source: Journal of Neurosurgery - Category: Neurosurgery Authors: Tags: J Neurosurg Source Type: research
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