Age effect on functional connectivity changes of right anterior insula after partial sleep deprivation

Neuroimaging studies revealed that emotion and cognition dysfunction after sleep deprivation is associated with the disturbance of the salience network. However, the age effect on the functional connectivity changes of the network after sleep deprivation remains unclear. The current study investigated the functional connectivity changes of the right anterior insula after partial sleep deprivation in young and old adults by using resting-state functional magnetic resonance imaging. We found a significant age × deprivation interaction effect on the functional connectivity between the right ventral anterior insula and the right ventral lateral prefrontal cortex and between the right dorsal anterior insula and the right anterior temporoparietal junction and left medial prefrontal cortex. Post-hoc analysis indicated that only young adults showed reduced functional connectivity of the right anterior insula. The changes in the functional connectivity between the right anterior insula and the right ventral lateral prefrontal cortex and anterior temporoparietal junction were negatively correlated with the insomnia severity index. Results suggested that sleep deprivation affects the salience network of young and old adults differently and highlighted the crucial role of age in sleep deprivation-related studies.
Source: NeuroReport - Category: Neurology Tags: Integrative Systems Source Type: research

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DiscussionThe study results will be used to clarify the effectiveness and elucidate the mechanism by which acupuncture improves sleep quality in patients with insomnia disorder.Trial registrationChinese Clinical Trials Register,ChiCTR1800015282. Registered on 20 March 2018.
Source: Trials - Category: Research Source Type: clinical trials
CONCLUSIONS: SW experience considerably more insomnia and mood disturbances than do DW, and this is significantly related to perfusion changes in multiple brain areas. PMID: 31591830 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research
AbstractInsomnia is a common sleep disorder among older adults, and a risk factor for poor physical and mental health. However, the relationship between insomnia and cognitive health is not well understood. Here, we review observational studies that have investigated whether insomnia is associated with deficits in objective cognitive performance and an increased risk of dementia, magnetic resonance imaging studies that have assessed grey matter volumes and white matter microstructure, and interventional studies that have explored whether the treatment of insomnia can improve cognitive outcomes. There are inconsistent findi...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Conclusions: The use of antidepressants, especially SNRIs, was associated with a shorter survival time of sCJD patients. The possible changes in neurotransmitters should be emphasized. Scientifically, this study may provide insights into the mechanism of CJD. Clinically, it may contribute to the early diagnosis of CJD.IntroductionDepression is common in the elderly. Its prevalence rate is as high as 11.19%, and this increases progressively with worsening cognitive impairment (1). The presence of depression is an acknowledged risk factor for dementia (2); it can even double the risk for Alzheimer’s disease (AD) (3, 4)...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Rui Yan1, ShiWan Tao1, HaiYan Liu1, Yu Chen1, JiaBo Shi1, YuYin Yang1, RongXin Zhu1, ZhiJian Yao1,2* and Qing Lu3,4*1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China2Nanjing Brain Hospital, Medical School of Nanjing University, Nanjing, China3School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China4Child Development and Learning Science, Key Laboratory of Ministry of Education, Nanjing, ChinaBackground: Major depressive disorders often involve somatic symptoms and have been found to have fundamental differences from non-somatic depressi...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
We examined the effects of the independent and combined effects of Zataria Multiflora supplementation and circuit resistance training (CRT) on selected adipokines among postmenopausal women. Forty-eight postmenopausal women were divided into four groups: Exercise (EG, n = 12), Zataria Multiflora (ZMG, n = 12), exercise and Zataria Multiflora (ZMEG, n = 12), and control (CG, n = 12). Participants in experimental groups either performed CRT (3 sessions per week with intensity at 55% of one-repetition maximum) or supplemented with Zataria Multiflora (500 mg every day after breakfast with 100 ml of water), or their combination...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study indicated that switch from H2 blockers to PPIs reduced delirium and, thus, providing an appropriate strategy to combat drug-induced delirium using antiulcer drugs (Fujii et al., 2012). The ventrolateral preoptic nucleus is a sleep-promoting nucleus located in the basal forebrain. A commonly used intravenous anesthetic, propofol, had been reported to induce sleep and augment the firing rate of neurons in ventrolateral GABAergic preoptic nucleus, but the underlining mechanism is yet to be clearly determined. Interestingly, the propofol-induced inhibition of inhibitory postsynaptic currents on noradrenalin-inhibite...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study is the first attempt to explore the gFCD feature in patients with PI. Our findings support the hyperarousal model of insomnia and suggest an imbalanced neural spontaneous fluctuation between anterior and posterior DMN in the resting state in patients with PI. These findings expand our understanding of the neuropathological mechanism of primary insomnia.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Insomnia disorder is a prevalent sleep disorder, which affects about 10% of general population. However, its neural mechanisms are poorly understood. Recently, several structural and functional neuroimaging studies have been conducted in patients with insomnia disorder, but these studies have yielded diverse findings. Here, we aimed to identify consistent patterns of abnormal brain alterations in insomnia disorder by performing a quantitative coordinate-based meta-analysis. Following the preferred reporting for systematic reviews and meta-analyses statement, we searched PubMed database and used reference tracking and final...
Source: Sleep Medicine Reviews - Category: Sleep Medicine Authors: Tags: Clinical Review Source Type: research
This study is the first attempt to explore the gFCD feature in patients with PI. Our findings support the hyperarousal model of insomnia and suggest an imbalanced neural spontaneous fluctuation between anterior and posterior DMN in the resting state in patients with PI. These findings expand our understanding of the neuropathological mechanism of primary insomnia.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
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