Atorvastatin attenuates spinal cord injury by chronic fluorosis in rats

In conclusion, the improvement of the function of the spinal cord in rats can be found when they were treated with atorvastatin.
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research

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Abstract During a spinal cord injury (SCI), mechanical trauma rapidly leads to a blood-spinal cord barrier (BSB) disruption, neural cell damage, axonal damage, and demyelination, followed by a cascade of secondary inflammatory reactions. These inflammatory responses spread the damage to the neural cells and impair the recovery of neurological functions. In the present study, we evaluated the efficacy of simvastatin and a simvastatin-ezetimibe combination therapy in managing the endothelial inflammatory response in an SCI rat model. Adult male Sprague-Dawley rats were group-housed and SCI was induced by using the m...
Source: Annals of Clinical and Laboratory Science - Category: Laboratory Medicine Authors: Tags: Ann Clin Lab Sci Source Type: research
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
DISCUSSION: Overall, the literature supports beneficial pleotropic effects of statin use in contrast-induced nephropathy, head injury, Alzheimer's and Parkinson's disease, nuclear cataract, prostate cancer, infection management, and spinal cord injury. Further investigation is warranted, and randomized clinical trials are needed to confirm the clinical utility suggested by the reported studies included in this meta-analysis. PMID: 30033872 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
Spinal cord ischemic injury remains a serious complication of open surgical and endovascular aortic procedures. Simvastatin has been reported to be associated with neuroprotective effect after spinal cord isch...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Research article Source Type: research
Conclusions: We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury. PMID: 29279745 [PubMed]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Condition:   Osteoporosis and Cardio-Metabolic Syndrome Following Spinal Cord Injury Interventions:   Drug: Rosuvastatin Calcium;   Drug: Placebo Oral Tablet;   Dietary Supplement: Coenzyme Q10;   Dietary Supplement: Calcium Carbonate;   Dietary Supplement: Vitamin D Sponsors:   Dr. B. Catharine. Craven;   The Craig H. Neilsen Foundation;   Toronto Rehabilitation Institute;   University Health Network, Toronto;   University of Miam...
Source: - Category: Research Source Type: clinical trials
Ischemia and the following reperfusion damage are critical mechanisms of spinal cord injury. Statins have been reported to decrease ischemia –reperfusion injury in many organs including the spinal cord. Anti-ox...
Source: Journal of Orthopaedic Surgery and Research - Category: Orthopaedics Authors: Source Type: research
This study was designed to reveal the role of RhoA signaling in the pathophysiology of neuropathic pain in mice. Partial sciatic nerve injury caused thermal hyperalgesia, mechanical allodynia, and increased plasma membrane translocation of RhoA in the lumber spinal cord. GFAP-immunoreactivity (ir), Iba-1-ir, and Rho kinase 2 (ROCK2-ir) was also increased in the ipsilateral spinal dorsal horn of nerve-ligated mice. Moreover, partial nerve ligation increased the expression of phosphorylated myristoylated alanine-rich protein kinase C substrate (MARCKS)-ir in the ipsilateral spinal dorsal horn. Daily intrathecal administratio...
Source: Neuroscience - Category: Neuroscience Source Type: research
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