Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders.

Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders. Aging (Albany NY). 2019 Nov 11;11: Authors: Li X, Chu SG, Shen XN, Hou XH, Xu W, Ou YN, Dong Q, Tan L, Yu JT, Alzheimer’s Disease Neuroimaging Initiative Abstract Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association study (GWAS) has identified seven loci associated with ventricular volume. The rate of ventricular enlargement increased in the progression of disease from normal cognition to dementia. Here, we aimed to use the rate of ventricular enlargement as an endophenotype for the development and progression of neurodegenerative diseases to discover more common genetic variants. We performed a GWAS of the rate of ventricular enlargement using 507 nondemented non-Hispanic white participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Linear regression model was used to identify the association of the rate of ventricular enlargement with single nucleotide polymorphisms (SNPs) in PLINK software. The associations of genome-wide significant SNPs with other four phenotypes were further discussed. Two SNPs (rs11620312, P = 4.04×10-8; rs79174114, P = 4.28×10-8) within SIAH3 gene in linkage disequilibrium (LD) reached genome-wide significance for association with increased rate of ventricular enlargement. Some intergenic SNPs ...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research