Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders.

Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders. Aging (Albany NY). 2019 Nov 11;11: Authors: Li X, Chu SG, Shen XN, Hou XH, Xu W, Ou YN, Dong Q, Tan L, Yu JT, Alzheimer’s Disease Neuroimaging Initiative Abstract Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association study (GWAS) has identified seven loci associated with ventricular volume. The rate of ventricular enlargement increased in the progression of disease from normal cognition to dementia. Here, we aimed to use the rate of ventricular enlargement as an endophenotype for the development and progression of neurodegenerative diseases to discover more common genetic variants. We performed a GWAS of the rate of ventricular enlargement using 507 nondemented non-Hispanic white participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Linear regression model was used to identify the association of the rate of ventricular enlargement with single nucleotide polymorphisms (SNPs) in PLINK software. The associations of genome-wide significant SNPs with other four phenotypes were further discussed. Two SNPs (rs11620312, P = 4.04×10-8; rs79174114, P = 4.28×10-8) within SIAH3 gene in linkage disequilibrium (LD) reached genome-wide significance for association with increased rate of ventricular enlargement. Some intergenic SNPs and SNP...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research

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Intercellular propagation of protein aggregation is emerging as a key mechanism in the progression of several neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia (FTD). However, we lack a systematic understanding of the cellular pathways controlling prion-like propagation of aggregation. To uncover such pathways, here we performed CRISPR interference (CRISPRi) screens in a human cell-based model of propagation of tau aggregation monitored by FRET. Our screens uncovered that knockdown of several components of the endosomal sorting complexes required for transport (ESCRT) machinery, includin...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Editors ' Picks Source Type: research
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Source: NeuroImage - Category: Neuroscience Source Type: research
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Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Alzheimer's / Dementia Source Type: news
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Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
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Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
You're reading How Does Sleeping Well Impact Brain Detoxification?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Have you been sleeping well lately? We all know that getting enough sleep is an important part of living a healthy and engaged life. Of course, getting a good night's sleep keeps you sharp during the day, and recent science has also shown how important it is in learning and memory. Sleep is not only good for helping you pay attention in class or remembering what you did yesterday though, it also helps keep ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness self improvement better sleep brain health science of sleep Source Type: blogs
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Editorial Source Type: research
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Source: International Journal of Neuroscience - Category: Neuroscience Authors: Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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