Safety, Tolerability, and Effects of Sodium Bicarbonate Inhalation in Cystic Fibrosis

ConclusionNebulized NaHCO3 inhalation appears to be a safe and well tolerated potential therapeutic agent in the management of CF. Nebulized NaHCO3 inhalation temporarily elevates airway liquid pH and reduces sputum viscosity and viscoelasticity.
Source: Clinical Drug Investigation - Category: Drugs & Pharmacology Source Type: research

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CONCLUSIONS: We found no evidence that adding hip core decompression to physical therapy achieves clinical improvement in people with sickle cell disease with avascular necrosis of bone compared to physical therapy alone. However, we highlight that our conclusion is based on one trial with high attrition rates. Further randomized controlled trials are necessary to evaluate the role of hip-core depression for this clinical condition. Endpoints should focus on participants' subjective experience (e.g. quality of life and pain) as well as more objective 'time-to-event' measures (e.g. mortality, survival, hip longevity). The a...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
FDA approved fewer drugs, but therapies for cystic fibrosis, postpartum depression stand out
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Background: Chronic respiratory diseases contribute to the development of anxiety and depression. In bronchiectasis (BE), it is unclear whether these comorbidities are related to general or disease-related quality of life (HRQoL) or symptoms.Aims: To evaluate the correlation between anxiety and depression and QoL in patients with BE.Methods: 26 subjects with non-cystic fibrosis BE of both sexes, 56±16 years, classified by the Bronchiectasis Severity Index (BSI), answered to the Mini Mental State Examination (MMSE), Anxiety and Depression Scale (HADS), Medical Outcomes Study 36 – Item Short – Form Health ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Conclusions: Although both instruments are specific for bronchiectasis, the results suggest that the severity of the disease-related neither with the perception of anxiety and depression, nor with the quality of life assessed by QoLB.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusion: A trial of the intervention to improve CPT adherence is feasible.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusions: We have shown that HAM-D does not correlate with BSI, so that regardless of the severity of non-CF BE, depression can worsen patients’ quality of life. Our experience points out a prevalent anxious rather than depressive profile in non-CF BE patients, that could be prompt recognized and treated.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Purpose of review Anxiety and depression (A&D) are common in cystic fibrosis (CF). This review defines A&D in the context of CF and examines our current knowledge about A&D, the impact on CF, treatment and illness trajectory and explores potential areas for prevention. Recent findings CF and A&D are interrelated. The CF diagnosis, symptoms and treatment may trigger symptoms of A&D, leading in some patients, to a clinical diagnosis of anxiety or depression. In return A&D impacts CF, potentially worsening the prognosis, decreasing treatment adherence and overall well being. Research shows how prevention is often imbedde...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: CYSTIC FIBROSIS: Edited by Harry G.M. Heijerman and Nick Simmonds Source Type: research
Children, adolescents, and young adults living with life-threatening serious pediatric illness (SPI) face considerable physical and emotional tolls via their disease conditions, treatment demands, and sequelae. To guide clinical interventions and future research for young people with SPI, Barker and colleagues conducted a meta-analysis to estimate the prevalence of anxiety and depression in children and young people with a variety of SPI, including cancer, cystic fibrosis, HIV, thalassemia, neurological conditions, and chronic kidney disease. The authors found that the prevalence of anxiety and depression is higher among y...
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research
AbstractIndividuals with cystic fibrosis (CF) are confronted by a range of difficult physical and psychosocial sequelae. Gratitude has drawn growing attention as a psychosocial resource, but it has yet to be examined among adults with CF. The current investigation evaluated longitudinal associations between trait gratitude and subsequent outcomes from depression screening 12  months later, adjusting for disease severity (FEV1% predicted) and other significant clinical or demographic covariates. Participants were 69 adult CF patients recruited from a regional adult treatment center. They completed a validated measure o...
Source: Journal of Behavioral Medicine - Category: Psychiatry Source Type: research
Condition:   Depression, Anxiety Interventions:   Behavioral: CF-CBT: A Cognitive-Behavioral Skills-Based Program to Promote Emotional Well-Being for Adults wtih Cystic Fibrosis;   Behavioral: Waitlist Control Sponsors:   Massachusetts General Hospital;   Cystic Fibrosis Foundation;   DeltaQuest Foundation, Inc.;   University at Buffalo;   University of Kansas Medical Center;   Stanford University;   Nicklaus Children's Hospital f/k/a Miami Children's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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