Analgesic and Respiratory Depressant Effects of R-dihydroetorphine A Pharmacokinetic –Pharmacodynamic Analysis in Healthy Male Volunteers

Conclusions Over the dose range studied, R-dihydroetorphine exhibited a plateau in respiratory depression, but not in analgesia. Whether these experimental advantages extrapolate to the clinical setting and whether analgesia has no plateau at higher concentrations than investigated requires further studies.
Source: Anesthesiology - Category: Anesthesiology Source Type: research

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Millions of people with post-traumatic stress disorder (PTSD) — from veterans to rape survivors — have new hope because of a watershed study showing that the injection of an anesthetic to a bundle of nerves in the neck can relieve their symptoms in a clinically significant way. The treatment is known as the stellate ganglion block, or SGB. Used since 1925 for problems such as pain in the arm and shingles, it is safe and effective. In the newly released, eight-week, U.S. Army-funded clinical trial of 108 active-duty service members with PTSD, the nonprofit research institute RTI International found that patients...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Personal PTSD Research Treatment Hyper Vigilance Neuroscience Neurotransmitter Norepinephrine Posttraumatic Stress Disorder pruning Source Type: blogs
Authors: Ali I, Alahdal M, Xia H, S El Moughrabi A, Shiqian H, Yao S Abstract Background: Emergence agitation is a reformed state of mindfulness, which starts with a sudden form of anesthesia and progresses through the early repossession age. Thus, the purpose of this study is to evaluate 1:3 ketofol performance on children 3-15 years old undergoing adenotonsillectomy.Methods: A total of 60 children aged 3-15 years undergoing adenotonsillectomy were randomly allocated to receive low-dose ketamine 0.15 mg/kg followed by propofol 0.45 mg/kg i.v. ketofol (1:3) about 10 min before the end of surgery in comparison to 60...
Source: Libyan Journal of Medicine - Category: General Medicine Tags: Libyan J Med Source Type: research
Authors: Pu J, Wang N, Huang ZK, He XY, Yuan HB Abstract OBJECTIVE: To explore the correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer. PATIENTS AND METHODS: Fifty-nine patients who underwent laparoscopic surgery for gastric or intestinal cancer under general anesthesia were included and randomly divided into oxycodone (n=30) and sufentanil groups (n=29) by reproducible random number generation method. Single nucleotide polymorphisms (SNPs) of four alleles: μ-opioid receptor gene OPRM1 A118G, cytochrome P450 (CPY450) enzyme system: CPY3A4*1G, CYP3A5*3, and ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: The results suggest that the activation of microglia in the hippocampus plays an important role in the development of pain and depressive-like behaviors in bone cancer condition. PMID: 31743195 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
What exactly is psychosis? What happens in the brain of a person with schizophrenia who is hallucinating? Schizophrenic Rachel Star Withers shares her personal hallucinations and delusions and Dr. Joseph Goldberg, who specializes in researching what goes on in the brain when someone is experiencing psychosis, joins to break down how the brain functions during psychotic episodes. Host Rachel Star Withers, a diagnosed schizophrenic, and co-host Gabe Howard delve into these intense subjects in this episode of Inside Schizophrenia.  Highlights from “Psychosis in Schizophrenia” Episode [02:13]  Rachel, do...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Brain and Behavior Disorders General Inside Schizophrenia Mental Health and Wellness Active psychosis Delusions Delusions Hallucinations Living with Schizoprenia Mental Disorder Mental Illness Psychology psychotic Psychotic Break Source Type: blogs
While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
The phrase “sacred masculine” can evoke images of patriarchal religiosity.  But it has a different meaning for today’s guest. For Miguel Dean, the sacred masculine is an ideal, embodied by a man who accepts all of his emotions, understands the connectedness of humanity, and is devoted to helping others. Join us as Miguel explains how the sacred masculine is increasingly being recognized as a new model of masculinity to replace the old ideas of what it meant to be a man. This new man embraces all of his humanity and recognizes that part of this is the courage to feel, express and honor the full spect...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Ethics & Morality General Inspiration & Hope Interview LifeHelper Men's Issues Podcast Relationships Self-Help Spirituality The Psych Central Show Source Type: blogs
CONCLUSION: Based on the deepening understanding of historical development and molecular targets and actions of modern anesthetics, novel general anesthetics are being investigated as potentially improved sedative-hypnotics or a key to understand the mechanism of anesthesia. PMID: 31724504 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Conclusions: Ganglion impar blockade decreases pain in the treatment of chronic coccydynia and improve depression. Addition of steroids in a ganglion impar blockade is required for treatment response that should accumulate over a long period of time. PMID: 31569923 [PubMed]
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Jeffrey A. SingerThe Drug Enforcement Administration, having virtually eliminated the diversion of prescription pain relievers into the underground market for nonmedical users, appears to be setting its sights on regulating the medical management of pain, a mission not suited for law enforcement. Acting under the authority of the Substance Use-Disorder Prevention that Promotes Opioid Recovery and Treatment for Patients and Communities Act (SUPPORT Act), the DEA  announced a proposal to reduce, once again, the national production quotas for fentanyl, morphine, hydromorphone (Dilaudid), oxycodone, and oxymorphone, ...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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