Anxiety in Older Adults With MDD on Venlafaxine Doesn ’t Reduce Chance of Remission, Study Finds

The presence of comorbid anxiety symptoms does not appear to predict the likelihood that older patients with major depressive disorder (MDD) will respond to the antidepressant venlafaxine, according to astudy inDepression&Anxiety.“[R]emission of depression was just as likely in more and less anxious participants,” Yasmina M. Saade, M.D., of Washington University in St. Louis and colleagues wrote.Previous studies show that older depressed adults with comorbid anxiety often have more severe depression symptoms and cognitive decline and are at greater risk of suicide compared with older depressed adults without anxiety. To examine whether comorbid anxiety influences response to treatment in older adults, Saade and colleagues analyzed data from the Incomplete Response in Late ‐Life Depression: Getting to Remission (IRL‐GRey) study, a large prospective antidepressant trial.For the first phase of the IRL-GRey study, 468 adults aged 60 years or older with MDD received open ‐label treatment with venlafaxine extended release, a selective serotonin and norepinephrine reuptake inhibitor. The participants were started at a dose of 37.5 mg/day and titrated up to 300 mg/day if they did not go into remission. Those who were taking a previously prescribed low-dose benzodiaze pine were permitted to continue its use. Before starting on venlafaxine, the researchers evaluated the participants using Montgomery-Åsberg Depression Rating Scale (MADRS), the Brief Symptom I...
Source: Psychiatr News - Category: Psychiatry Tags: anxiety depression & IRL ‐GRey study MADRS MDD older adults suicide ideation Venlafaxine Yasmina M. Saade Source Type: research

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AbstractTo investigate which factors individuals with a psychotic depression experience as preventive of suicide while beeing hospitalized. Semi-structured qualitative interviews with nine inpatients, all hospitalized for a unipolar or bipolar depressive episode with psychosis, were conducted at time of discharge. For analysis we used systematic text condensation. Main outcomes were accounts of participants ’ experiences of suicide prevention measures and treatment, and how these affected suicidal ideation, plans, and attempts. Participants experienced (1) suicide attempts being physically interrupted or prevented; (...
Source: Psychiatric Quarterly - Category: Psychiatry Source Type: research
ConclusionsWeight loss is insufficient to determine a change in psychological distress following surgery. Physicians and other health professionals who treat bariatric surgery patients should be encouraged to asses BID pre- and post-surgery, as it is a sensitive indicator of improvement of psychological well-being after surgery.
Source: Obesity Surgery - Category: Surgery Source Type: research
AbstractPurpose of reviewEating disorders are common in childhood and adolescence and have the highest mortality rate of the mental illnesses, largely due to the medical complications of malnutrition. Psychiatric co-morbidities can lead to death by suicide. Despite a dearth of evidence on the topic, psychiatrists are often asked to comment on the potential utility of adding psychotropic medications to the treatment plan.Recent findingsIt is challenging to recruit patients with eating disorders to medication studies. There are no psychotropic medications approved for the treatment of eating disorders in children and adolesc...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
Millions of people with post-traumatic stress disorder (PTSD) — from veterans to rape survivors — have new hope because of a watershed study showing that the injection of an anesthetic to a bundle of nerves in the neck can relieve their symptoms in a clinically significant way. The treatment is known as the stellate ganglion block, or SGB. Used since 1925 for problems such as pain in the arm and shingles, it is safe and effective. In the newly released, eight-week, U.S. Army-funded clinical trial of 108 active-duty service members with PTSD, the nonprofit research institute RTI International found that patients...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Personal PTSD Research Treatment Hyper Vigilance Neuroscience Neurotransmitter Norepinephrine Posttraumatic Stress Disorder pruning Source Type: blogs
Authors: Silveira C, Guedes R, Maia D, Curral R, Coelho R Abstract Multiple Sclerosis (MS) is a chronic disabling neuroinflammatory disease. Psychiatric manifestations have a high prevalence in MS patients and may worsen the illness progression and the patients' quality of life (QoL). Depression is a highly prevalent condition in MS patients, associated with poorer adherence to treatment, decreased functional status and QoL, and increased suicide risk. Diagnosis and treatment of this disorder is challenging because of symptom overlap. Other prevalent psychiatric comorbidities are anxiety disorders, bipolar disorder...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
ConclusionsRumination is known to be associated with poor prognosis in mental health. This study suggests that rumination is a maladaptive coping style associated not only with worry, distress and illness severity, but also with socioeconomic status. Also, rumination demonstrated a specific association with panic disorder.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
CONCLUSIONS: Psychological and relational issues mostly distinguished the three classes. Despite differing frequency of hotline usage, most texters who reported suicidal ideation and behaviors endorsed similar issues, and these issues did not seem to vary across conversations. Yet there appeared to be distinct subgroups of texters with different presenting issues, which may inform how crisis counselors tailor strategies for both low- and high-volume texters. PMID: 31795857 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
(Taylor&Francis Group) Psychological support for those dealing with infertility and its treatment is received by only just half of those who want it in the UK - with many left to suffer with anxiety, depression, or suicidal thoughts, according to a new study published in Human Fertility.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Background: Suicide is the second leading cause of death in young people worldwide. Self-harm is the strongest predictor of death by suicide. There is increasing evidence that psychological therapies are efficacious in treating self-harm in adolescents. However, studies so far have predominantly focused on highly selective groups of adolescents and have investigated interventions that require intensive training and considerable expense.Methods: We conducted a pilot study of a novel psychological therapy package, Specialized Therapeutic Assessment-Based Recovery-Focused Treatment (START) that consists of Therapeutic Assessm...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Abstract The American Medical Society for Sports Medicine convened a panel of experts to provide an evidence-based, best practices document to assist sports medicine physicians and other members of the athletic care network with the detection, treatment and prevention of mental health issues in competitive athletes. This statement discusses how members of the sports medicine team, including team physicians, athletic trainers and mental health providers, work together in providing comprehensive psychological care to athletes. It specifically addresses psychological factors in athletes including personality issues a...
Source: British Journal of Sports Medicine - Category: Sports Medicine Authors: Tags: Br J Sports Med Source Type: research
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