Beyond a Ribosomal RNA Methyltransferase, the Wider Role of MraW in DNA Methylation, Motility and Colonization in Escherichia coli O157:H7

In conclusion, mraW was found to be a DNA methylase and have a wide-ranging effect on E. coli O157:H7 including motility and virulence in vivo via genome wide methylation and mraZ antagonism.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research

Related Links:

Publication date: Available online 9 December 2019Source: PolymerAuthor(s): O.I. Timaeva, N.A. Arkharova, A.S. Orekhov, V.V. Klechkovskaya, S.P. Mulakov, G.M. Kuz'micheva, I.I. PashkinAbstractComposite hydrogels in the poly-N-vinylpyrrolidone – RE(NO3)3 × xH2O system with RE = La, Gd, Yb were prepared in various forms (native, native dried in the air, dried in air and ground into powder). They were studied by methods of wide- and small-angle X-ray scattering, differential scanning calorimetry, scanning electron microscopy, and electron microprobe analysis. The composition of native PVP and PVP with powd...
Source: Polymer - Category: Chemistry Source Type: research
Six new dihydroisocoumarins, aspergimarins A−F (1−6), were discovered together with five known analogs (7−11) from a monoculture of the sponge-derived fungus Aspergillus sp. NBUF87. The structures of these compounds were elucidated through comprehensive spectroscopic methods, and absolute configurations were assigned after X-ray crystallography, use of the modified Mosher’s method, and comparison of electronic circular dichroism (ECD) data with literature values for previously reported analogs. Compounds 1−11 were evaluated in a variety of bioassays, and at 100 μM, both 1 and 5 showed signi...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 6 December 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Sai Kumar Tammina, Yang Wan, Yan Yan Li, Yaling YangAbstractA simple and one-step microwave digestion method was utilized to synthesize the highly photoluminescent glucosamine derived nitrogen and zinc doped carbon dots (N, Zn-CDs) with a bluish-green luminescence property. The synthesized N, Zn-CDs inherited a good photoluminescence property with a quantum yield of 74% and which were characterized with XPS, XRD, TEM, FT-IR, UV–Vis, and fluorescence spectrometry. More importantly N, Zn-CDs served ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 5 December 2019Source: Materials LettersAuthor(s): Sheena Raina, Anupma Thakur, Aditi Sharma, D. Pooja, Anu Priya MinhasAbstractThe present was the first report on the synthesis of Carbon dots (CDs) using the acetone leaf extract of Cannabis sativa, an abundant weed plant as a sole carbon precursor. The obtained ∼5 nm spherical CD particles (exhibiting 13% absolute quantum yield) were further to synthesize silver@CDs (Ag@CDs). CDs and Ag@CDs characterization revealed characteristic functional groups attributing to the aromatic, carboxylated and hydroxylated moieties. Ether and acetone...
Source: Materials Letters - Category: Materials Science Source Type: research
Conclusion: It was found that the majority of POEs containing a bioreducible center showed higher inhibitory activities on Mtb growth when compared to the similar compounds without a bio-reducible functional group. PMID: 31799156 [PubMed]
Source: BioImpacts - Category: Research Tags: Bioimpacts Source Type: research
Publication date: March 2020Source: Materials Science and Engineering: C, Volume 108Author(s): Agni Kumar Biswal, Hariprasad P., Sampa SahaAbstractSimple addition of a minute quantity of non-toxic mustard oil in water/oil/water (W/O/W) double emulsion led to a porous morphology at the surface as well as in the interior of the biodegradable PLGA (Poly(l-lactide-co-glycolide)) microparticles. An attempt was made to understand the mechanism of pore formation by analyzing optical micrographs and SEM images in addition to solution viscosity of organic phase and interfacial tension values between organic and aqueous phases. The ...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 2 December 2019Source: Journal of Molecular StructureAuthor(s): R. Rama, S. MeenakshiAbstractA novel Aliquat 336 based functionalized ionic liquid, methyltrioctylammonium naphthylacetate ([A336]+[NAA]-) have been synthesized and characterized using IR, UV, 1H NMR and Raman spectroscopy techniques. The prepared IL was tested for antimicrobial properties and chromium (VI) extraction. Anti-bacterial test was carried out towards five types of bacteria namely Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Bacillus subtilis and Salmonella typhi. The antifungal test was done ou...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Abstract Condensation of rhodanine (1) with pyrazol-3(2H)-one derivatives (2a-f) gave 5-substituted-2-thioxo-1,3-thiazolidin-4-one derivatives (3a-f). Reaction of compound (1) with 2-arylmethylidene-malononitrile (4a-d) yielded the unexpected derivatives (5a-d). The latter compounds were subjected to cyclization reactions with malononitrile under different basic conditions, hydroxylamine hydrochloride and/or thiourea to furnish the fused thiazole derivatives (6a-d) and (8-10a-d). Coupling of (1) with diazotized aromatic amines (11a-c) in pyridine afforded the arylhydrazones (12a-c). Fusion of latter compounds with...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Publication date: Available online 21 November 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Yan He, Yue Zhang, Madi Sun, Chao Yang, Xiao Zheng, Chengxin Shi, Zhimin Chang, Zheng Wang, Jinying Chen, Shuchen Pei, Wen-fei Dong, Dan Shao, Junjun SheAbstractChlorhexidine (CHX) is a widely used antiseptic in various infection control practices. In this work, we have developed biodegradable mesoporous organosilica nanoparticles (MONs) through a one-pot synthesis by employing CHX as a bifunctional agent that not any acts as a cationic template to form the structure of mesopores but also serves as a broad-spectrum a...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 3 December 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Rajasree Shanmuganathan, Felix LewisOscar, Sabarathinam Shanmugam, Nooruddin Thajuddin, Sulaiman Ali Alharbi, Naiyf S. Alharbi, Kathirvel Brindhadevi, Arivalagan PugazhendhiAbstractBacterial pathogenicity is becoming a major cause of morbidity and mortality around the globe. Researchers are tirelessly finding solutions to cure or prevent infections caused by bacterial pathogens. Nanotechnology is a fast-growing area of research, effectively influencing and preventing bacterial growth. Nanoparticles (NPs...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
More News: Gastroenteritis | Genetics | Microbiology | Staphylococcus Aureus | Study