Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines.

Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 09;:1-16 Authors: Biswas A, Chakrabarti AK, Dutta S Abstract Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the individual from acquiring infection and further decimation, although recent estimates suggest that overall flu vaccine effectiveness was within 19% to 53% in last five years. A significant weakness of current vaccination is its inability to protect an individual from different or mutant flu strain. Host immune system performs a vital role during natural infection or after vaccination leading to influenza-specific immunities. Previous imprints of common flu or vaccination may alter the outcomes of the current vaccination. Current flu vaccine regime does not consider the host immune status before vaccination. Irrespective of the previous influenza exposure history or prior flu vaccination, individual get flu vaccination based on WHO recommendation with selected strains which may be the reason why induction of broad immunities does not transpire with their testimonial. Over the last few decades, scientific res...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research

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While the world awaits a proven COVID-19 vaccine, medical experts are turning their attention to a shot that’s long been a key component in the public health toolbox: the flu vaccine. Experts hope this year’s flu shot can help prevent an influenza epidemic paired with another wave of coronavirus, which could overwhelm hospitals and lead to general confusion, given that it can be difficult to tell a COVID-19 infection from a case of the flu. This flu season is also something of a dress rehearsal for the eventual rollout of a COVID-19 vaccine amid the ongoing pandemic, allowing doctors, nurses and pharmacists a c...
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An influenza epidemic alongside the ongoing COVID-19 pandemic -- it's the "twindemic" that health officials are trying to avoid. Dr. Gregory Poland, a Mayo Clinic vaccine expert, explains why getting a flu vaccination is so important. Watch: The Mayo Clinic Minute https://youtu.be/RnxmIRevkZE Journalists: Broadcast-quality video (0:59) is in the downloads at the end of this [...]
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We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
r U Abstract For a long time, most of the infectious diseases seemed to have become under control. In particular, vaccinations have contributed to this development. In recent years newly occurring bacterial infections caused by multidrug-resistant pathogens and viral infections, such as the chikungunya virus, influenza epidemics and currently the COVID-19 pandemic, are endangering the world population. This specifically affects patients with rheumatological diseases, who often require immunosuppressive therapy and are thus at risk for infections. Vaccinations can protect those affected, both individually and ...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Magazine Source Type: news
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post Why COVID-19 Vaccines Need to Prioritize ‘Superspreaders’ appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health COVID-19 Source Type: news
By FARZAD MOSTASHARI In Partnership with Resolve to Save Lives, Carnegie Mellon University, and University of Maryland, Catalyst @ Health 2.0 is excited to announce the launch of The COVID-19 Symptom Data Challenge. The COVID-19 Symptom Data Challenge is looking for novel analytic approaches that use COVID-19 Symptom Survey data to enable earlier detection and improved situational awareness of the outbreak by public health and the public.  How the Challenge Works: In Phase I, innovators submit a white paper (“digital poster”) summarizing the approach, methods, analysis, findings, relevant figures...
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Over the past few years, Professor Zhang Yongzhen has made it his business to sequence thousands of previously unknown viruses. But he knew straight away that this one was particularly nasty. It was about 1:30 p.m. on Jan. 3 that a metal box arrived at the drab, beige buildings that house the Shanghai Public Health Clinical Center. Inside was a test tube packed in dry ice that contained swabs from a patient suffering from a peculiar pneumonia sweeping China’s central city of Wuhan. But little did Zhang know that that box would also unleash a vicious squall of blame and geopolitical acrimony worthy of Pandora herself....
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 overnight Source Type: news
Over the past few years, Professor Zhang Yongzhen has made it his business to sequence thousands of previously unknown viruses. But he knew straight away that this one was particularly nasty. It was about 1:30 p.m. on Jan. 3 that a metal box arrived at the drab, beige buildings that house the Shanghai Public Health Clinical Center. Inside was a test tube packed in dry ice that contained swabs from a patient suffering from a peculiar pneumonia sweeping China’s central city of Wuhan. But little did Zhang know that that box would also unleash a vicious squall of blame and geopolitical acrimony worthy of Pandora herself....
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 overnight Source Type: news
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Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Democracy Headlines Health Source Type: news
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