99m TcMIBI SPECT/CT for Identifying Dystonic Muscles in Patients with Primary Cervical Dystonia

This study aimed to evaluate the usefulness of [99mTc]sestamibi ([99mTc]MIBI) single photon emission computed tomography (SPECT)/X-ray computed tomography (CT) imaging for the identification of dystonic muscles in primary cervical dystonia (PCD) patients who underwent botulinum neurotoxin type A (BoNT-A) therapy.ProceduresThirty-six patients with PCD and 10 healthy subjects (control group) who underwent [99mTc]MIBI SPECT/CT were enrolled. The image characteristics of dystonic muscles and normal muscles were evaluated. Muscle/background ratio (MBR) of six representative muscles was calculated for dystonic muscles in PCD group and normal muscles in control group. In PCD patients, target muscles injected with BoNT-A were selected by clinical evaluations and the results of needle electromyography (EMG) were considered as the gold standard. The sensitivity, specificity, and diagnostic efficacy of SPECT/CT were obtained from the receiver operator characteristic (ROC) curve.ResultsTwenty-four PCD patients were included in our study eventually, because three PCD patients whose follow-up were lost and 9 PCD patients whose maximum reduction of Tsui scale scores was
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research

Related Links:

ConclusionsAbnormal gait may be observed as a primary FGD or in patients with other FMDs appearing during gait; both conditions are common and may cause disability.
Source: Neurological Sciences - Category: Neurology Source Type: research
Dropped head syndrome (DHS) can be the presenting feature of a wide spectrum of neurological conditions affecting the central and peripheral nervous systems, and can be due to underlying neck extension weakness or dystonia. Among central disorders, DHS can be seen in patients with parkinsonism (Parkinson disease or multiple system atrophy) where it can be due to underlying dystonia, myopathy, or a combination of both. [1,2] Among neuromuscular disorders, DHS can be the presenting symptom of an underlying motor neuron disease, defect of neuromuscular transmission (including myasthenia gravis, congenital myasthenia and Lambe...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Consider treatment with levodopa in patients with Fahr syndrome and extrapyramidal symptoms.
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Dystonia, Basal ganglia Case Source Type: research
During a hospitalization for sepsis in the setting of a urinary tract infection, a 69-year-old man with idiopathic Parkinson disease (PD) developed severe, sudden-onset left-sided neck pain an hour after receiving quetiapine to treat hospital delirium, raising concern for acute dystonic reaction. On review of the patient's history, he had received single doses of haloperidol and quetiapine 1 week and 3 days prior, respectively, without documented dystonic reaction. He had a history of dystonia in his right foot, which was well controlled with botulinum toxin injections. On examination, his head was rotated toward the right...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: Clinical neurology examination, All Movement Disorders, Dystonia, Parkinson's disease/Parkinsonism, Botulinum toxin Case Source Type: research
Publication date: Available online 7 December 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Vanna Micheli, Gabriella Jacomelli, Annalisa Santucci, Giulia BernardiniLesch–Nyhan Disease (LND) is a rare X-linked recessive metabolic and neurological syndrome due to the deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT). Peculiar neurological symptoms occur in LND: dystonia, choreoathetosis, compulsive self-injurious behaviour, with no obvious correlation to the deficiency of this purine salvage anzyme. A dopaminergic deficit was found to underlie the neurologic symptoms, but the aetiology fo...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research
A 24-year-old woman with an unresectable right mesencephalic pilocytic astrocytoma was treated with stereotaxic radiation therapy. Three months after a radiation therapy–induced bleeding, she presented a severe disabling low frequency rest and kinetic tremor involving the left upper limb, associated with dystonia, and a Holmes tremor was suspected. Thereby, we performed a 123I-FP-CIT SPECT (DATSCAN) that revealed a normal distribution of radiotracer over the left striatum, whereas no binding was seen in the right caudate and putamen. This pattern was consistent with a right severe nigrostriatal dopaminergic denervati...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
CONCLUSIONS: Genetic analysis along with thorough clinical analysis supported by radiological findings will aid the differential diagnosis of MPAN within the neurodegeneration with brain iron accumulation spectrum as well as other disorders including hereditary spastic paraplegia. Dystonia and parkinsonism may not be the leading clinical findings in MPAN patients, as these are absent in the atypical case. Finally, we emphasise that the existence of frameshifting variants may bias the age of onset toward childhood. PMID: 31804703 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - Category: Neurology Authors: Tags: Neurol Neurochir Pol Source Type: research
Fine motor control of not only muscle contraction but also muscle relaxation is required for appropriate movements in both daily life and sports. Movement disorders such as Parkinson’s disease and dystonia are often characterized by deficits of muscle relaxation. Neuroimaging and neurophysiological studies suggest that muscle relaxation is an active process requiring cortical activation, and not just the cessation of contraction. In this article, we review the neural mechanisms of muscle relaxation, primarily utilizing research involving transcranial magnetic stimulation (TMS). Several studies utilizing single-pulse ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Abstract The TWNK (C10orf2) gene encodes Twinkle, an essential helicase for mtDNA replication. Homozygous mutations in TWNK can lead to mitochondrial DNA depletion syndrome 7 (MTDPS7) that usually manifests as Infantile onset spinocerebellar ataxia (IOSCA). Here, we report a 15-year-old Iranian boy with three main symptoms; ataxia, sensorineural hearing loss and optic nerves atrophy which were accompanied by other symptoms including flexion contracture, dysarthric speech, nystagmus, dystonia and borderline intellectual disability. Whole exome sequencing (WES) revealed a homozygous mutation in his TWNK gene. The mu...
Source: Archives of Iranian Medicine - Category: Middle East Health Authors: Tags: Arch Iran Med Source Type: research
Abstract GLUT1 deficiency is a rare neurometabolic disorder that can be effectively treated with ketogenic diet. However, this condition is underdiagnosed due to its nonspecific, overlapping, and evolving symptoms with age. We retrospectively reviewed the clinical course of nine patients diagnosed with GLUT1 deficiency, based on SLC2A1 mutations and/or glucose concentration in cerebrospinal fluid. The patients included eight boys and one girl who initially presented with seizures (44%, 4/9) or delayed development (44%, 4/9) before 2 years of age, except for one patient who presented with apnea as a neonate. Over t...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
More News: Biology | Brain | CT Scan | Dystonia | Molecular Biology | Neurology | SPECT | Study