Different Metabolism of EPA, DPA and DHA in humans: a double-blind cross-over study

Considerable research supporting the beneficial biological effects of n-3 long-chain polyunsaturated fatty acids (LCP) have shown that these LCP contribute to preventing and improving chronic disease outcomes, including metabolic disease, cardiovascular diseases (CVD), non-alcoholic fatty liver disease and some kinds of cancers [1-3]. A large proportion of these studies have focused on fish oils, which commonly contain three kinds of n-3 LCP, namely eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA).
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Source Type: research

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ra Florea The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in the general population prompts for a quick response from physicians. As NAFLD can progress to liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC), new non-invasive, rapid, cost-effective diagnostic methods are needed. In this review, we explore the diagnostic performance of ultrasound elastography for non-invasive assessment of NAFLD and NAFLD-related HCC. Elastography provides a new dimension to the conventional ultrasound examination, by adding the liver stiffness quantification in the diagnostic algorithm. Whilst the m...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
arritt Hepatocellular carcinoma (HCC) is a considerable health burden worldwide and a major contributor to cancer-related deaths. HCC is often not noticed until at an advanced stage where treatment options are limited and current systemic drugs can usually only prolong survival for a short time. Understanding the biology and pathology of HCC is a challenge, due to the cellular and anatomic complexities of the liver. While not yet fully understood, liver cancer stem cells play a central role in the initiation and progression of HCC and in resistance to drugs. There are approximately twenty Ca2+-signaling proteins identi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Authors: Tan PO, Mustaffa N, Tan SS, Lee YY Abstract Globally, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly and constitutes a significant healthcare burden due to associated complications including hepatic (cirrhosis and hepatocellular cancer) and non-hepatic (cardiovascular deaths) disorders. It is closely linked to insulin resistance and metabolic syndrome but moderate alcohol consumption frequently coexists. Recently, genetic polymorphisms were implicated in the development of non-obese NAFLD. Apart from liver biopsy, in order to assess for steatosis, fibrosis and non-alcohol...
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Authors: Shao M, Ye Z, Qin Y, Wu T Abstract Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and can lead to liver cirrhosis or liver cancer in severe cases. In recent years, the incidence of NAFLD has increased substantially. The trend has continued to increase and has become a key point of concern for health systems. NAFLD is often associated with metabolic abnormalities caused by increased visceral obesity, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, atherosclerosis and systemic microinflammation. Therefore, the pathophysiological mechani...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In conclusion, long-term feeding of either HFHF or WDHC are reliable methods to induce NASH and diet-potentiated liver cancer in mice of both sexes; however, the choice of diet involves a trade-off between severity of metabolic syndrome and liver damage. PMID: 32924526 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - Category: Endocrinology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research
o Amedeo Columbano Activation of the Nrf2-Keap1 pathway, the main intracellular defense against environmental stress, has been observed in several human cancers, including hepatocellular carcinoma (HCC). Here, we assessed whether distinct mechanisms of activation may be involved at different stages of hepatocarcinogenesis. We adopted an experimental model consisting of treatment with diethylnitrosamine (DENA) followed by a choline-devoid methionine-deficient (CMD) diet for 4 months. The CMD diet was then replaced with a basal diet, and the animals were killed at 6, 10 or 13 months after DENA injection. Nrf2 activatio...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Authors: Anastasopoulos NT, Lianos GD, Tatsi V, Karampa A, Goussia A, Glantzounis GK Abstract INTRODUCTION: The indisputable increase in non-Alcoholic Fatty Liver Disease (NAFLD) prevalence, has consequently led to an increase in Hepatocellular Carcinoma (HCC) and liver-related mortality worldwide. Twenty-five percent of the general population present with various degrees of steatosis and most of them are unaware of their disease until its progression to advanced stages The characteristics of patients with HCC, secondary to NAFLD, are older age, large tumours due to late diagnosis, often without cirrhosis and high ...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Abstract Fatty acid synthase (FASN) is a multifunctional enzyme involved in the production of fatty acids for lipid biosynthesis. FASN is overexpressed in multiple diseases like cancer, viral, non-alcoholic fatty liver disease and metabolic disorders making it an attractive target for new drug discovery for these diseases. In cancer, FASN affects the structure and function of the cellular membrane by channelizing with signaling pathways along with the post-translational palmitoylation of proteins. There are several natural and synthetic FASN inhibitors reported in the literature, a few examples are GSK 2194069 (7....
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
The prevalence of non-alcoholic fatty liver disease (NAFLD) and its advanced form, i.e. non-alcoholic steatohepatitis (NASH), in the general population are increasing worldwide, reaching 45 and 6.5%, respectively [1,2]. NAFLD, and especially NASH, have been associated with increased cardiovascular (CV) morbidity and mortality, as well as all-cause death and cancer development [3 –12]. Furthermore, there is a bidirectional relationship between NAFLD/NASH and type 2 diabetes mellitus (T2DM). Indeed, in T2DM patients, the prevalence of NAFLD may exceed 70%, whereas for NASH it can reach 50% [13].
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Tags: Editorial Source Type: research
CONCLUSIONS: The ALIOS diet in mice recapitulates many of the clinical features of NAFLD and therefore represents a robust and reproducible model for investigating the pathogenesis of NAFLD and its progression. PMID: 32755310 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - Category: Physiology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
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