UTSA researchers discover new pathways in brain's amygdala

(University of Texas at San Antonio) The University of Texas at San Antonio (UTSA) researchers are pioneering an innovative brain study that sheds light on how the amygdala portion of the brain functions and could contribute to a better understanding of post-traumatic stress disorder, anxiety, depression and Alzheimer's disease.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Neuropsychiatric symptoms (NPS) are now recognized as a major component of neurocognitive disorders, such as Alzheimer's disease (AD) and frontotemporal dementia (FTD). NPS in dementia, also referred to as behavioral and psychological symptoms of dementia (BPSD), can take various forms, including: psychotic symptoms, mood disturbances (e.g., depressive symptoms and anxiety), and socially inappropriate behaviours.1,2 NPS are highly prevalent in the course of these disorders, with a large cross-sectional study reporting up to 80% of individuals exhibiting a clinically significant neuropsychiatric manifestation after onset of...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
? Rethinking and Retooling Brain Health and Mental Health from SharpBrains Hoping you enjoy this slidedeck supporting a great discussion held during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7–9th).  Full recordings are available for purchase here. 9–10.30am. How to detect problems early: Examples in Alzheimer’s Disease, Parkinson’s, anxiety and PTSD Dr. Srijan Sen, Professor of Depression and Neurosciences at University of Michigan Jan Samzelius, Co-Founder and Chief Scientist of NeuraMetrix Dr. Tony Chang, Associate at Merck V...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Alzheimer’s Disease anxiety brain health early detection Parkinsons PTSD Source Type: blogs
Sandip T. Auti and Yogesh A. Kulkarni* Shobhaben Pratapbhai Patel School of Pharmacy &Technology Management, SVKM's NMIMS, Mumbai, India Acetylcholinesterase (AChE) is an enzyme involved in the progression of Alzheimer's disease (AD). Cardamom oil (CO) has been reported to have acetylcholinesterase inhibitory, antioxidant and anti-anxiety effects. Hence, we studied the effect of cardamom oil in aluminum chloride induced neurotoxicity in rats. AD like symptoms were induced in Wistar rats with aluminum chloride (100 mg/kg, p.o.). Cardamom oil was administered concomitantly by oral route at doses...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
DiscussionAs detailed above, the “elements” in both a classical and a contemporary sense have effects on our mental health and are potentially modifiable aspects that can be harnessed as therapeutic interventions. The most robust interventional evidence currently available shows tentative support for several use of the elements via horticultural and nature-exposure therapy, green exercise/physical activity, sauna and heat therapy, balneotherapy, and breathing exercises. It should be noted that, in many cases, these interventions were not studied in definitive diagnosed psychiatric disorders and thus it is prema...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
In this study, a link between mitochondrial changes and infant temperament has also been suggested. Maternal psychosocial stress and lifetime trauma have been associated with decreased mitochondrial DNA copy number in the placenta (115, 116).IndividualityChronic stress links changes in the epigenetic landscape with health conditions (117). Different cell types are characterized by distinct patterns of gene expression due to developmental, environmental, physiological, and pathological reasons (117). Epigenetic mechanisms affect gene function in a dynamic way as a result of different environmental exposures during fetal dev...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain functio...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In conclusion, the studies presented in the current review demonstrate that CBD has the potential to limit delta-9-THC-induced cognitive impairment and improve cognitive function in various pathological conditions. Human studies suggest that CBD may have a protective role in delta-9-THC-induced cognitive impairments; however, there is limited human evidence for CBD treatment effects in pathological states (e.g. schizophrenia). In short, they found that CBD may help alleviate the negative impact of a person with schizophrenia from taking cannabis, both in the psychotic and cognitive symptoms associated with schizophrenia. T...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Disorders General Research Treatment cannabidiol Cannabis cbd cbd oil Marijuana THC Source Type: blogs
This study examined the link between depression/anxiety/PTSD and dementia by evaluating the prevalence of these disorders in people with dementia, relative to their healthy peers. Existing meta-analyses have examined the prevalence of clinically-significant depression and anxiety in Alzheimer ’s disease (AD), and depression in frontotemporal dementia (FTD), but have not considered vascular dementia (VaD), dementia with Lewy bodies (DLB), PTSD, or anxiety in FTD. The current meta-analysis compared the prevalence of clinically-significant depression, anxiety and PTSD in the four most com mon types of dementia (AD, VaD,...
Source: Neuropsychology Review - Category: Neuroscience Source Type: research
UCLA biologists have discovered how head injuries adversely affect individual cells and genes  that can lead to serious brain disorders. The life scientists provide the first cell “atlas” of the hippocampus — the part of the brain that helps regulate learning and memory — when it is affected by traumatic brain injury. The team also proposes gene candidates for treating brain disease s associated with traumatic brain injury, such as Alzheimer’s disease and post-traumatic stress disorder.The researchers studied more than 6,000 cells in 15 hippocampal cell types — the first study of in...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The Middle East and North Africa (MENA) face daunting challenges in managing a growing burden of mental illness, often in adverse conditions that can leave their imprint on generations to come.While the burden of mental-health conditions is above the global average in most MENA countries, the human resources, policies, funding and infrastructure to deal with these problems are sorely lacking.According to a recent study led by the Institute for Health Metrics and Evaluation (IHME), mental disorders excluding substance abuse accounted for 4.7% of all disability-adjusted life years (DALYs) in the World Health Organization &rs...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
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