Cardiac resynchronization therapy benefits cancer survivors with heart failure

(University of Rochester Medical Center) A pacemaker-like device restored heart function in a group of cancer survivors -- mostly women with breast cancer -- who had suffered from heart failure as a result of chemotherapy treatment, a study in the Journal of the American Medical Association (JAMA) reports.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Adjuvant radiotherapy following breast-conserving surgery decreases local recurrences and improves survival outcomes in breast cancer [1,2]. However, radiotherapy is associated with an increased risk of cardiovascular complications as a result of cardiac irradiation, including ischemic heart disease [3-5], valvulopathy [3,6-9], congestive heart failure [3,5], myocarditis [9], arrhythmia [3] and myocardial infarction [5,10]. A case control study has demonstrated an increased risk of major coronary events by 7.4% for every Gy increase in mean dose to the heart [11].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Socioeconomic status can help predict whether a person will die from heart...Read more on AuntMinnie.comRelated Reading: COVID-19 patients at risk for heart complications Cardiac CT shows promise for osteoporosis screening Breast cancer mortality higher after heart attack Echocardiography reveals heart changes in WNBA players DiA gets FDA nod, CE Mark for AI-based ultrasound tools
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
DISCUSSION: In our large real-world investigation, T-associated cardiotoxicity was limited to the treatment period. The addition of T to adjuvant CT did not result in long-term worsening of CV events. IMPLICATION FOR PRACTICE: Adjuvant trastuzumab-based chemotherapy represents the backbone therapy in HER2 positive early breast cancer patients. Although well tolerated, cardiovascular events can manifest during or after therapy due to treatment-related toxicities. In our wide multicentre and unselected cohort, long-term symptomatic cardiotoxicity was low and limited to the treatment period. The findings suggest that dev...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
Chemotherapy has led to improved survival in patients with breast cancer; however, it is associated with an increased risk of cardiac dysfunction and heart failure. We investigated the protective effects of rosuvastatin and candesartan, alone and in combination, in a doxorubicin- and trastuzumab-induced rat model of cardiomyopathy.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Source Type: research
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
CONCLUSION: This nationwide study showed that standard chemotherapy with low-dose anthracycline is a risk factor for late-onset CHF in breast cancer survivors who were in their 50 s at breast cancer diagnosis. Long-term monitoring of late CHF should be considered in these younger breast cancer survivors. PMID: 32771950 [PubMed - as supplied by publisher]
Source: Breast - Category: Cancer & Oncology Authors: Tags: Breast Source Type: research
Conclusion: The variations in frequency of and reasons for hospitalization, ED/OB stays, and hospitalization discharge destinations across cancer types should be considered when evaluating OCM practice performance. PMID: 32715807 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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