Management of Children with Tuberculosis

Children carry a significant tuberculosis disease burden in settings with poor epidemic control and high levels of transmission. Even in high-resource settings, the diagnosis of tuberculosis in children can be challenging, but an accurate diagnosis can be achieved by adopting a systematic approach. This review outlines the general principles of tuberculosis prevention in children, including epidemic control, infection control, contact tracing and preventive therapy, and vaccination; diagnosing pediatric tuberculosis, including specimen collection and microbiological confirmation, highlighting key differences from adults; and tuberculosis treatment in children, including treatment of severe disease that mostly occurs in young children and drug-resistant tuberculosis.
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research

Related Links:

We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
By Anis Chowdhury and Jomo Kwame SundaramSYDNEY and KUALA LUMPUR, May 26 2020 (IPS) With well over five million Covid-19 infections worldwide, and deaths exceeding 340,000, the race for an effective vaccine has accelerated since the SARS-Cov-2 virus was first identified as the culprit. Expecting to score politically from being ‘first’ to have a vaccine, US President Trump’s Operation Warp Speed promises to get 300 million doses to Americans by January, after the November polls, following several failed attempts to monopolize vaccines being developed by European companies. Anis Chowdhury More than 115 vac...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Economy & Trade Featured Global Headlines Health Humanitarian Emergencies TerraViva United Nations Jomo Kwame Sundaram & Anis Chowdhury Source Type: news
ov VV Abstract Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more than 130 years ago, nowadays only old vaccine (Bacillus Calmette-Guérin vaccine) and classical toxic drugs that are losing its effectiveness are available in clinic practice. Despite enormous efforts in drug research on TB treatment including vaccines and diagnostics investigations, this old contagious, infectious disease is still a major public health problem. The goal of elimina...
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
In this study we show for the first time the interaction between MTB Beijing-genotype strains and BCG-vaccinated hosts. Using a well-controlled murine model of progressive pulmonary tuberculosis, we vaccinated BALB/c mice with two different sub-strains of BCG (BCG-Phipps and BCG-Vietnam). Following vaccination, the mice were infected with either one of three selected MTB strains. Strains were selected based on lineage, and included two Beijing-family clinical isolates (strains 46 and 48) and a well-characterized laboratory strain (H37Rv). Two months after infection, mice were euthanized and the bacteria extracted from thei...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The map from the medical journal Plos Medicine displays BCG vaccination policy by country. Bacillus Calmette-Guérin vaccine is a vaccine primarily used against tuberculosis. Yellow: The country now has a universal BCG vaccination program. Blue: The country used to recommend BCG vaccination for everyone, but now does not. Red: The country never had a universal vaccination program.By Darini Rajasingham-SenanayakeCOLOMBO, Sri Lanka, Apr 20 2020 (IPS) Numerous studies in many parts of the world have linked the BCG (Bacillus Calmette-Guerin) vaccination, widely used in the developing world with fewer Coronavirus cases. T...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Economy & Trade Featured Global Headlines Health TerraViva United Nations Source Type: news
Funding Opportunity RFA-AI-20-023 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications to continue the International epidemiology Databases to Evaluate AIDS (IeDEA) Program. The IeDEA program is comprised of 7 regional data center awards, which bring together clinical and research data within regions, and in collaboration monitor and guide the response to the HIV/AIDS epidemic. This research includes work on the long-term impact of HIV and its treatment, the epidemiology of common co-infections (e.g., hepatitis and tuberculosis). Research also evaluates health care...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
This article includes reporting by Ivet González in Havana, Mario Osava in Rio de Janeiro, and Orlando Milesi in Santiago. The post Latin America Has Weak Defences Against the Pandemic appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Editors' Choice Featured Headlines Health Human Rights Latin America & the Caribbean Population Regional Categories Coronavirus COVID-19 ECLAC Pan-American Health Organization (PAHO) Poverty World Health Organ Source Type: news
Credit: UNBy Ifeanyi Nsofor and Adaeze OrehABUJA, Mar 30 2020 (IPS) As COVID-19 surges globally and leaves fear and panic in its wake, global efforts are underway to find a cure. Yet, the same level of response is lacking for several other infectious diseases that kill millions annually. These kinds of neglected tropical diseases (NTDs) are a broad group of communicable diseases which affect more than two billion people and cost developing economies billions of dollars every year. Lassa Fever is an example and is endemic in Nigeria and other West African countries such as Benin, Ghana, Guinea, Liberia, ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Neglected Tropical Diseases (NTDs) Source Type: news
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post TB, HIV and COVID-19: Urgent Questions as Three Epidemics Collide appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Headlines Health Source Type: news
Authors: Tandel N, Joseph AZ, Joshi A, Shrama P, Mishra RP, Tyagi RK, Bisen PS Abstract Introduction: Tuberculosis (TB) is still one of the major global health threats and delayed diagnosis or misdiagnosis continues to fuel the global epidemic. The conventional diagnostic approaches have shortcomings that might hinder the process of diagnosis of the disease and ultimately affect the prognosis.Area Covered: We emphasize on the process of the synthesis of liposomes, its physicochemical properties affecting the formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a ligh...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
More News: Children | Epidemics | Epidemiology | Microbiology | Pediatrics | Respiratory Medicine | Tuberculosis | Vaccines