Invasive fungal disease with isavuconazole treatment failure diagnosed using a combination of fungal biomarkers

Invasive fungal disease with isavuconazole treatment failure diagnosed using a combination of fungal biomarkersConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Publication date: Available online 6 December 2019Source: Journal de Mycologie MédicaleAuthor(s): Peiying Chen, Juan Liu, Meihua Zeng, Hong SangAbstractAspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and laboratory studies in recent years with applications of molecular biotechnology including next-generation sequencing, reverse genetics and so on. In this review, current research on the molecular mech...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
Abstract SUMMARYAspergilli produce conidia for reproduction or to survive hostile conditions, and they are highly effective in the distribution of conidia through the environment. In immunocompromised individuals, inhaled conidia can germinate inside the respiratory tract, which may result in invasive pulmonary aspergillosis. The management of invasive aspergillosis has become more complex, with new risk groups being identified and the emergence of antifungal resistance. Patient survival is threatened by these developments, stressing the need for alternative therapeutic strategies. As germination is crucial for in...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Microbiol Mol Biol Rev Source Type: research
Publication date: Available online 5 December 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Aoi Miyamoto, Chihiro Kadooka, Kazuki Mori, Yuki Tagawa, Kayu Okutsu, Yumiko Yoshizaki, Kazunori Takamine, Masatoshi Goto, Hisanori Tamaki, Taiki FutagamiSirtuins are understood to play a significant role in growth phase-dependent gene expression. In the study presented here, we examined the sirtuins in the white koji fungus, Aspergillus luchuensis mut. kawachii (Aspergillus kawachii), to examine their role in the regulation of amylolytic enzymes and citric acid production during solid-state culture (koji). Characte...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Publication date: February 2020Source: Phytochemistry, Volume 170Author(s): Changhong Huo, Xinhua Lu, Zhihui Zheng, Yeying Li, Yan Xu, Haizhou Zheng, Yuanchen NiuAbstractSix undescribed azaphilones, deflectins C1-C3, deflectins D1-D2, and deflectin E, along with five known azaphilones were obtained from a solid culture of the wild fungus Aspergillus deflectus NCC0415. Their structures were determined by HRESIMS, NMR and ECD analyses, together with the GIAO 13C NMR calculation method. All compounds displayed strong or moderate inhibitory activity against protein tyrosine phosphatases SHP2 and PTP1B. Structure-activity relat...
Source: Phytochemistry - Category: Chemistry Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
In this study, a novel glucose oxidase gene, CngoxA, from Cladosporium neopsychrotolerans SL16, was cloned and expressed in Pichia pastoris. Recombinant CnGOXA exhibited maximal activity at 20 ℃ and pH 7.0, and was stable at 30 ℃ and pH 6.0–9.0 for 1 h, with a half-life of 15 min at 40 ℃. Compared with CnGOXA, the half-life of its mutant CnGOXA-M1 (Y169C-A211C), at 40 °C increased approximately 48-fold, and was stable at 30 ℃ and pH 3.0–12.0 for 1 h. The kcat and catalytic efficiency of CnGOXA-M1 were enhanced 0.7- and 1.6-fold, respectively. Both enzymes were cold-adapted and highly resistant to SD...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 4 December 2019Source: Food ChemistryAuthor(s): Jian Ju, Yunfei Xie, Hang Yu, Yahui Guo, Yuliang Cheng, Rongrong Zhang, Weirong YaoAbstractConsumers’ preferences for cleaner label products require the food industry to replace synthetic preservatives with natural substitutes. Therefore, the synergistic inhibitory effect of eugenol and citral (SEC) on Aspergillus niger was explored. On this basis, the antimicrobial sachet containing SEC was developed and its application potential in bread preservation was evaluated. The content of reactive oxygen species (ROS) and malondialdehyde (MDA...
Source: Food Chemistry - Category: Food Science Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
In this study, using a reporter gene system in yeast, we identified the C-terminal region of ClrB/CLR-2 as a transcriptional activation domain. Expression of clrBID, encoding a ClrB derivative in which the DNA-binding and transcriptional activation domains are fused together to remove the middle region, led to cellulase production in the absence of cellulose in P. oxalicum. Strikingly, the clrBID-expressing strain produced cellulase on carbon sources that normally repress cellulase expression, including glucose and glycerol. Results from deletion of the carbon catabolite repressor gene creA in the clrBID-expressing strain ...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
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