Reproducibility of hepatic MR elastography across field strengths, pulse sequences, scan intervals, and readers

ConclusionThe magnitude of change across combinations of scan parameters is within acceptable clinical range, rendering liver stiffness through MRE a reproducible quantitative imaging biomarker. A lower reproducibility was observed for measurements under different field strengths/MRE sequences at a longer (2  weeks) interscan interval. Operators should be trained to acquire region of interest consistently in repeat examinations.
Source: Abdominal Imaging - Category: Radiology Source Type: research

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Abstract Systemic lupus erythematosus (SLE), a multisystem autoimmune inflammatory disease, may involve any organs, including the liver. Liver involvement in SLE is not part of the American College of Rheumatology criteria and is relatively rare. Liver disease is usually mild, manifesting as subtle elevation of liver enzymes. Jaundice and hepatomegaly can be seen in some patients; advanced liver disease with cirrhosis is extremely rare. Precise pathology remains obscure. SLE may cause non-specific changes, including hepatocellular, cholestatic, or vascular changes. Alcohol, drugs, viral infections, metabolic disor...
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
Authors: Baek J, Jung SJ, Shim JS, Jeon YW, Seo E, Kim HC Abstract OBJECTIVES: We compared the associations of 3 computed tomography (CT)-based abdominal adiposity indexes with non-alcoholic fatty liver disease (NAFLD) among middle-aged Korean men and women. METHODS: The participants were 1366 men and 2480 women community-dwellers aged 30-64 years. Three abdominal adiposity indexes-visceral fat area (VFA), subcutaneous fat area (SFA), and visceral-to-subcutaneous fat ratio (VSR)-were calculated from abdominal CT scans. NAFLD was determined by calculating the Liver Fat Score from comorbidities and blood tests. A...
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
CONCLUSIONS: Our study shows that a high adherence to the MD decreases the risk of NAFLD. PMID: 32706078 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Conclusions: These findings will provide guidance to clinicians and patients on the use of n-3 PUFAs for NAFLD. Ethics and dissemination: This study is a protocol for a systematic review of n-3 PUFAs as a treatment of NAFLD patients. This review will be published in a journal and disseminated in print by peer-review. Systematic review registration: INPLASY202050008.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
ConclusionsPatients who receive neoadjuvant chemotherapy for liver metastasis surgery have a greater splenic volume increase, which correlates with NAFLD and a lower survival.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Condition:   Non-alcoholic Fatty Liver Disease (NAFLD) Interventions:   Drug: Metabolic Cofactor Supplementation;   Drug: Sorbitol Sponsors:   ScandiBio Therapeutics AB;   Koç University;   Koç University Hospital;   Göteborg University;   Sahlgrenska University Hospital, Sweden;   KTH Royal Institute of Technology;   University of Helsinki;   Helsinki University Central Hospital;   Monitor CRO Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionSegment IV b seems to be the most vulnerable site for fat deposition; focal lesions here should be carefully evaluated. Segments II, III and VII seem to closely represent MHD.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research
CONCLUSION: We found that maternal OWOB status is related to fatty liver content in the offspring as young adults, even after taking into account OWOB status and lifestyle factors in the offspring. PMID: 32145139 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
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