ASN: Difelikefalin Improves Itch in CKD-Linked Pruritus

TUESDAY, Nov. 12, 2019 -- For patients undergoing hemodialysis who have moderate-to-severe pruritus, difelikefalin is associated with a significant reduction in itch intensity and improvement in itch-related quality of life, according to a study...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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The objective was to determine whether changes in parathyroid hormone (PTH) levels are associated with changes in symptoms within this patient population.Study DesignProspective cohort.Setting &Participants165 adults with hyperparathyroidism secondary to kidney failure diagnosed, a range of dialysis vintages, and receiving regular hemodialysis from a US single-provider organization.ExposureChange in PTH levels over 24 weeks.Outcomes19 putative symptoms of secondary hyperparathyroidism measured up to 4 times using a self-administered questionnaire that assessed severity on a 5-level ordinal scale.Analytical ApproachLong...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conclusion and Future Directions G protein bias may either be affinity/potency-dominant or efficacy-dominant (Table 1). A potential concern is that, despite using the same cellular assays, variations in agonist potency were determined by different, or even the same labs, potentially due to differences in expression levels of the receptor and signaling proteins that occurred during cell passaging. For example the reported arrestin recruitment potency for U69,593 has been reported to be as low as 67.7 nM (Spetea et al., 2017) and as high as 410 nM (Dunn et al., 2018), similarly for U50,488 potency has ranged from 36 to 1000...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: Better skin management is needed for itch in patients with ESRD or CKD. Moisturizing and lifestyle factors are important. Topical or oral medications may also be used. Nalfurafine, a κ receptor agonist, is now available in Japan for the treatment of uremic pruritus in these patients.Blood Purif 2019;47(suppl 2):1 –5
Source: Blood Purification - Category: Hematology Source Type: research
A 51-year-old woman with a history of end-stage renal disease, on hemodialysis for 4years, hypertension and diabetes mellitus type II presented with an extremely itchy diffuse skin rash that she initially noticed two weeks prior to presentation. The itching was significant enough to impair her quality of life and she has tried applying various over the counter anti-itch creams without much relief. Examination of the skin was notable for diffusely scattered blackish hyperpigmented, dome-shaped, umbilicated papules, some coalescing into plaques on the trunk and extremities.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
A 51-year-old woman with a history of end-stage renal disease, hypertension, and diabetes mellitus type 2 who had been on hemodialysis for 4 years presented with an extremely itchy diffuse skin rash that she initially noticed 2 weeks prior to presentation. The itching was significant enough to impair her quality of life, and she had tried applying various over-the-counter anti-itch creams without much relief. Examination of the skin was notable for diffusely scattered blackish hyperpigmented, dome-shaped, umbilicated papules, some coalescing into plaques on the trunk and extremities.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Communication to the Editor Source Type: research
This study demonstrates a high mortality in HD patients; however, mortality depends on itch intensity, not on the occurrence of CI itself. PMID: 30673111 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research
Conclusion: Improvement of sleep quality and quality of life among patients with CKD-associated pruritus requires great importance. This study aims to improve the quality of sleep and quality of life among patients with hemodialysis suffering from CKD-associated pruritus.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, ...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch® capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus. Int J Nephrol Renovasc Dis. 2018;11:9-24 Authors: Kozono H, Yoshitani H, Nakano R Abstract Background: Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a po...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
A 64-year-old woman came to the emergency department complaining of cough, shortness of breath, itchy throat, and runny nose. She had end-stage renal disease and was on hemodialysis three times per week; she also had hypertension and type 2 diabetes and had undergone a left below-knee amputation. Her serum creatinine was 9.48 mg/dL; a typical value for adult women is 0.5 to 1.1 mg/dL. She was transferred to the hemodialysis unit where she underwent hemodialysis and was then admitted to the medical floor.
Source: AORN Journal - Category: Nursing Tags: Column Source Type: research
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