Intravenous immunoglobulins for the prevention of postpartum relapses in multiple sclerosis

ConclusionThis study provides no evidence of benefit for postpartum administration of IVIG in women with RRMS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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WEDNESDAY, Dec. 11, 2019 -- Women with multiple sclerosis often find that their symptoms ease during pregnancy. And evidence is growing that breastfeeding might have a similar benefit. A new review of 16 studies found that overall, women with MS...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Publication date: Available online 25 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): R. Lanzillo, M. Moccia, R. Palladino, E. Signoriello, A. Carotenuto, G.T. Maniscalco, F. Saccà, S. Bonavita, C.V. Russo, R. Iodice, M. Petruzzo, L. Sinisi, M. De Angelis, L. Lavorgna, A. De Rosa, F. Romano, V. Orlando, B. Ronga, C. Florio, G. LusAbstractBackgroundDimethyl-fumarate (DMF) was effective and safe in relapsing–remitting multiple sclerosis (MS) in randomized clinical trials. We aimed to evaluate the efficacy and safety of DMF and factors related to drug response in real-life setting.MethodsW...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 23 November 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): De Giglio L, Federici S, Ruggieri S, Borriello G, D'Errico MA, De Angelis C, Pozzilli CAbstractA multidisciplinary approach is needed for the management of pregnancy related issues in women affected by Multiple Sclerosis, however little attention has been devoted to the modality of delivery. Here we aimed to investigate whether the diagnosis of multiple sclerosis (MS) influences delivery modality in MS patients. Patients who received the diagnosis before pregnancy showed a lower frequency of natural delivery and a ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This article reviews the immunomodulatory role of vitamin D in autoimmune diseases and pregnancy. In particular, we will describe the role of vitamin D from conception until delivery, including the health of the offspring. This review highlights an observational study where hypovitaminosis D was correlated with decreased fertility, increased disease activity, placental insufficiency, and preeclampsia in women with APS.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Natalizumab (NTZ) is a humanized monoclonal antibody that targets alpha4-integrins reducing leukocytes trafficking across the blood brain barrier [9]. Although NTZ has an unquestionable efficacy on disease activity in relapsing-remitting Multiple Sclerosis (RRMS), its safety profile has been questioned. Progressive multifocal leukoencephalopathy is the most frightening adverse event during NTZ-treatment [10]. However other NTZ-induced side effects have been described, including haematological disorders, particularly frequent in the newborns after NTZ-exposure during pregnancy [5].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
We report a woman with multiple sclerosis who discontinued fingolimod in the first month of her pregnancy. She developed severe disease rebound which responded poorly to steroids. She was started on rituximab, which was continued during the rest of her pregnancy and beyond. Rituximab appeared safe and well tolerated by both mother and infant, and could be considered in pregnancy for those patients with multiple sclerosis who are at high risk of gestational and postpartum relapse.
Source: Case Reports in Womens Health - Category: OBGYN Source Type: research
The feeling of abandonment can span through all types of relationships and in this episode, we focus on friendships. Have you ever had a close friend abandon you or have you ever exited a friendship without notice? The emotions and actions surrounding the abandonment of friends can be complex and hurtful, but they are very real and can hurt deeply.  In this episode, Jackie recounts friendships that were very important to her and how she’s handling the loss of them. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who live...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Family Friends General Grief and Loss Not Crazy Podcast Relationships Source Type: blogs
What can we expect from the flu season this year? Unfortunately, many experts are predicting an active, and possibly severe, flu season. This projection is based on data from Australia, where the flu season is just wrapping up. Australia was hit early and hard by flu this year: over 300,000 patients had laboratory-confirmed influenza, a record number of cases. Flu outbreaks in the Southern Hemisphere happen during our summers, and they often give us a clue as to what we should expect when the flu lands on our shores in the fall. Who should get the flu vaccine? Basically, everybody over the age of 6 months, except for those...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cold and Flu Health Prevention Vaccines Source Type: blogs
ConclusionFindings are consistent with a low rate of RTX interruptions, with pregnancy and adverse events as most frequent reasons. A small proportion of patients switched due to breakthrough disease in context of incomplete B-lymphocyte depletion. Signs of ongoing disease activity in the remaining group was low regardless of whether a new DMT was started. These findings are consistent with a long acting effect of RTX in RRMS and absence of rebound disease activity phenomena upon stopping therapy.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We describe a series of cases of rebound syndrome after the cessation of fingolimod due to pregnancy planning.Methods: The clinical and radiological data of 7 MS patients who discontinued fingolimod therapy between May 2012 and March 2018 to plan a pregnancy was analysed.Results: Three (42.8%) of the 7 patients experienced a rebound effect, all of whom became pregnant. During pregnancy, the 3 patients had a mean (SD) of 5.3 (1.3) relapses, and 13 of the 15 relapses were treated with intravenous steroids and/or immunoglobulin. These patients experienced a median increase of 3 points in the Expanded Disability Status Scale (...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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