Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial

This study is registered with the Netherlands Trial Registry, number NTR5263.FindingsWe screened patients for enrolment between Dec 3, 2015, and May 31, 2018. Patients completed baseline visits and started treatment between Dec 14, 2015, and July 2, 2018, and the last study visit of the last patient was Oct 4, 2018. Of 149 patients assessed for eligibility, 57 (38%) patients were excluded (predominantly because they did not meet one or several inclusion criteria, most often because of an absence of synovial inflammation or of flare-ups after NSAID washout) and 92 (62%) patients were eligible for inclusion. We randomly assigned 46 (50%) patients to receive prednisolone and 46 (50%) patients to receive placebo, all of whom were included in the modified intention-to-treat analysis of the primary endpoint. 42 (91%) patients in the prednisolone group and 42 (91%) in the placebo group completed the 14-week study. The mean change between baseline and week 6 on VAS-reported finger pain was −21·5 (SD 21·7) in the prednisolone group and −5·2 (24·3) in the placebo group, with a mean between-group difference (of prednisolone vs placebo) of −16·5 (95% CI −26·1 to −6·9; p=0·0007). The number of non-serious adverse events was similar between the groups. Five serious adverse events were reported during our study: one serious adverse event in the prednisolone group (a myocardial infarction) and four serious ...
Source: The Lancet - Category: General Medicine Source Type: research

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teo D Abstract Background: Altered balance is a common and debilitating symptom of fibromyalgia. Previous studies have investigated balance under single-task conditions that do not reflect real-life situations. The present study evaluated the impact of a simultaneous cell-phone conversation on balance performance in a case-control cohort from Spain. Methods: A cross-sectional case-control study was performed in 34 women recruited from local self-help organizations and university facilities (n = 18 fibromyalgia cases; n = 16 healthy, pain-free controls). Participants performed the 3...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease. Biomed Res Int. 2019;2019:1030256 Authors: Coto-Segura P, Coto E, González-Lara L, Alonso B, Gómez J, Cuesta-Llavona E, Queiro R Abstract Background and Aims: The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common pol...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
CONCLUSIONS: Spinal shrinkage equally affects men and women who perform the same work. There are no changes in spinal sagittal alignment throughout the workday in office workers. Office workers increase pain in the upper back significantly at the end of the day. PMID: 31813341 [PubMed - as supplied by publisher]
Source: International Journal of Occupational Safety and Ergonomics - Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research
Not only FAST The MUSEC® experience in training surgeons. Ann Ital Chir. 2019;90:373-378 Authors: Marconi M, Mariani D, La Greca A, Casas IM, Pereira J, da Silva AR, Pinheiro L, Casamassima A, Bass G, Ponchietti L, Zago M Abstract For a long time surgeons have been discussing the need to improve their skills in the use of ultrasound (US). However in the recent years it has become evident the importancxe for general aklnd trauma surgeons treating critically-ill patients to learn basic and advanced US. The two last editions (9th and 10th) of the ATLS manual have officially included FAST and e-FAST in...
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): Kevin Coetzee, Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Peter HumaidanAbstractResearch questionWhat is the effect of frozen embryo transfer (FET) on infant birth weight outcomes and which variables predic large-for-gestational age (LGA) infants.DesignIn a large cohort study, the birth weight of 1295 singleton live births from blastocyst freeze-all-IVF treatments carried out between February 2015 and February 2017 at a single IVF centre were analysed. All embryo transfers were vitrified–warmed blastocyst transfers i...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
We describe a family ascertained through 3 newborn screening (NBS) positive infants found to be unaffected themselves but in whom the mothers (sisters) were affected. There were also two affected children born to an affected male and his heterozygous wife who were false negatives on NBS but had increased fractional excretion of free carnitine in the urine. Analysis on a Next Generation Sequencing panel specifically designed to fully cover newborn screening disease targets showed a homozygous change in the five probands (SLC22A5; NM_003060:c.-149G > A; p.?). The mutation segregates with the CUD within the family. It ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Harish Seethapathy, Lama NoureddineCalciphylaxis is a rare disorder of poor prognosis that can lead to intense, painful lesions involving the skin and subcutaneous tissue. Although mostly described in dialysis patients, it can affect patients with normal kidney function. The diagnosis of calciphylaxis is complicated by the absence of a gold standard marker of disease such as a clear histopathological finding. Late diagnosis and advanced lesions can significantly shorten life expectancy. Calciphylaxis wounds can have a ma...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
hi all, I have a patient with a history of an anterior cervical fusion present with a 2 month history of cervical radic that hasn't responded to NSAID, PT, oral steroids, or even percocet. She wants to have an epidural done but has this history of VWF disease. I don't have any records about and she isn't entirely clear about this diagnosis. She just told me "they told me I bled a lot after a prior surgery and diagnosed me with VWF disease". She did tell me she received DDAVP prior to her... cervical esi and VWF disease
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Authors: Lin ZM, Wen Q, Yan CX, Pan MQ, Mo GQ, Chen JF, Huang PT Abstract The aim of the present study was to investigate the benefits of combining contrast-enhanced ultrasound (CEUS) and strain elastography (SE) for the diagnosis of thyroid nodules with non-diagnostic fine-needle aspiration cytology (FNAC) results. Between October 2013 and March 2017, CEUS and SE were performed in 226 patients (236 thyroid nodules) with non-diagnostic FNAC results prior to thyroidectomy. The diagnostic value of CEUS, SE and their combination (CEUS+SE) in distinguishing malignant from benign thyroid nodules was evaluated, using sur...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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