Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
In conclusion, PD may serve as a pharmaceutic candidate for obesity-related lipid metabolism, anti-inflammation, and body weight loss. PMID: 31828124 [PubMed - in process]
Publication date: 12 December 2019Source: Cell, Volume 179, Issue 7Author(s): Cross-Disorder Group of the Psychiatric Genomics ConsortiumSummaryGenetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette synd...
Conclusion: This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. PMID: 31823595 [PubMed - as supplied by publisher]
It was in fourth and fifth grade that I decided I didn’t want to grow up. I wanted to be the shortest in my classes, and I even walked around with bent knees to appear shorter. I remember competing with friends to see who could come closest to being able to fit our hands around our waists. I remember having a friend over and watching a Richard Simmons “Sweatin’ to the Oldies” exercise video and then having us both get on the scale to compare weights. I was just a little girl and I don’t know where this idea came from. This was way back in the mid-90s when there were few resources for children ...
This study is registered with Clinicaltrials.gov, number NCT02560025, and has completed enrolment.FindingsBetween Dec 31, 2015, and Aug 1, 2017, we enrolled a total of 39 eligible patients. 19 (49%) of 39 patients had secondary acute myeloid leukaemia and three (8%) had therapy-related acute myeloid leukaemia. At mid-induction, 33 (85%) of 39 patients showed marrow aplasia, six (15%) received re-induction. The median follow-up was 13·7 months (IQR 12·7–14·4). Composite remission was 64% (two-stage 95% CI 48–79), with 20 (51%) of 39 patients achieving complete remission and five (13%) achiev...
Superior mesenteric artery syndrome presents with nonspecific GI complaints, hindering weight restoration in those with anorexia nervosa. Diagnosis is made with radiologic testing, and treatment requires only weight restoration, negating the need for surgical intervention. AbstractSuperior mesenteric artery syndrome presents with nonspecific GI complaints, hindering weight restoration in those with anorexia nervosa. Diagnosis is made with radiologic testing, and treatment requires only weight restoration, negating the need for surgical intervention.
Conditions: Anorexia Nervosa; Avoidant/Restrictive Food Intake Disorder; Anxiety Intervention: Other: Weighted blanket Sponsor: Denver Health and Hospital Authority Completed
CONCLUSIONS: Olanzapine remains a useful antipsychotic albeit with careful monitoring. Further research is needed to compare the different options available to mitigate olanzapine-induced weight gain and to evaluate potential synergism between pharmacological and non-pharmacological treatments. PMID: 31813311 [PubMed - as supplied by publisher]
CONCLUSION: This study demonstrated that weight extremes (AN or OB) influence aBMD, bone remodeling and periostin profiles. Moreover, factors related to aBMD were specific to each condition, but LBM was the parameter most consistently associated with aBMD. PMID: 31821467 [PubMed - as supplied by publisher]
Conclusion: Xiaoyaosan ameliorates CIS-induced depression-like behaviors and anorexia by regulating the NES1-OT-POMC neural pathway in the hypothalamus.