Dispersive Liquid-liquid Microextraction with High-Performance Liquid Chromatography for the Analysis of 1,4-benzodioxane-6-aldehyde in Eliglustat Tartrate Active Pharmaceutical Ingredient
Publication date: Available online 12 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yixuan Cui, Di Liu, Jing Bian, Yuke Yang, Mengqiang Zhao, Ye JiangAbstractPotential genotoxic impurities (PGIs) are a series of compounds that could potentially damage DNA. Therefore, a sensitive method is needed for detection and quantification. The present work described and validated a method for the quantification of one PGI (namely 1,4-benzodioxane-6-aldehyde) in Eliglustat tartrate (EGT) active pharmaceutical ingredient (API) substances using dispersive liquid-liquid microextraction (DLLME) as sample preparation to remove matrix effect and detected by HPLC-UV. Parameters influencing the microextraction efficiency were systematically investigated. The combined application of DLLME and HPLC-UV provided the sensitivity of the method. The achieved limit of detection (LOD) and the limit of quantification (LOQ) were adequate for the specific purpose and found to be 1.29 µg g-1 and 2.58 µg g-1, respectively. This simple and effective methodology offers a key advantage in the ease of removing matrix effect and improves sensitivity obviously. In addition, no costly instrumentation and skilled personnel are needed when using this method, which is available and can be successfully implemented in routine factory drug quality control analysis.
Antioxidants&Redox Signaling, Ahead of Print.
Publication date: Available online 10 December 2019Source: Seminars in Ultrasound, CT and MRIAuthor(s): Satheesh Krishna, Ashley Leckie, Ania Kielar, Robert Hartman, Ashish KhandelwalAbstractCystic renal masses are common incidental findings on cross-sectional imaging. Accurate characterisation of cystic renal masses is essential to guide management. Renal mass protocol comprises of a good quality non-contrast, corticomedullary and nephrographic phases with each phase providing complementary information for diagnosis. Attenuation measurements in different phases are central to the ‘golden-rules’ in renal mass i...
This article reviews the risks and benefits of GBCA administration.
Publication date: Available online 10 December 2019Source: European Journal of RadiologyAuthor(s): Arun Jose, Akhil Kher, Robert E. O’Donnell, Jean M. ElwingAbstractPurposeTargeted treatment for pulmonary arterial hypertension (PAH), diagnosed via right heart catheterization (RHC), has been shown to improve morbidity and mortality. Identifying characteristics that predict clinical worsening has been challenging. We sought to evaluate the role of cardiac Magnetic Resonance Imaging (CMR) as a predictor of clinical worsening in a cohort of treatment-naïve pulmonary hypertension (PH) patients.MethodsWe performed a r...
Events: Conference Call Bayer 2030 Sustainable Development ObjectivesLive today at approx. 2:00 p.m. CET (1:00 p.m. UTC): Investor Conference Call: Bayer 2030 Sustainable Development ObjectivesLink to websiteAll changes
Bayer to significantly step-up its sustainability efforts2030 target to be carbon neutral in own operations / Ambitious 2030 objectives for access to health and nutrition in low- and middle-income countries and underserved communities / Measurable sustainability targets to be incorporated into management compensationmehr ...
to the article “Attachment Disorders,” by Gail Hornor, published in the September/October 2019 issue of the Journal (Journal of Pediatric Health Care, 33, 612–622).
This article presents a case report that illustrates how evasive the diagnosis of pericardial effusion can be. The early symptoms of pericardial effusion resemble common viral conditions that can easily be overlooked. Subtle presenting symptoms and the importance of urgent multidisciplinary collaboration and emergent referral for the child with pericarditis are summarized.
This article provides an overview of CALMs, followed by a summary of several conditions associated with CALMs ranging from the most common (neurofibromatosis type 1) to rare, ring chromosome syndromes.