Developing Novel Therapies for Stimulant Use Disorder - 12/16/2019 - 12/16/2019

In recent years, there has been an increase in the number of overdoses that involve a psychostimulant, such as methamphetamine, cocaine, or prescription. In response to growing rates of stimulant misuse, addiction, and overdose, stakeholders across the U.S. health care system are working to implement strategies designed to ensure that patients with
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news

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The overprescribing of opioid pain relievers (OPR) has led to a significant increase in opioid addiction and overdose. A cornerstone of combating the opioid epidemic is the development of peri-operative evidence based guidelines to standardize OPR prescribing practices and of opioid sparing Enhanced Recovery After Surgery (ERAS) protocols. ERAS has been found to reduce the volume of OPR prescribed while improving outcomes and overall patient satisfaction in adult gynecologic and multiple pediatric surgical specialties.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
CONCLUSIONS AND SCIENTIFIC SIGNIFICANCE: This report provides the first-ever description of trends and characteristics of overdose mortality and opioid-involved deaths among US Veterans of military service for the period 2010 to 2016. With the exception of female Veterans and Veterans in Western States, it has been found that trends in Veteran overdose mortality paralleled rising rates of drug overdose observed in the United States more broadly. Published 2020. This article is a U.S. Government work and is in the public domain in the USA. (Am J Addict 2020;00:00-00). PMID: 32223045 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research
This report uses data from the 2015-2018 National Surveys on Drug Use and Health (NSDUHs) to estimate methamphetamine use rates in the United States and to identify characteristics associated with past-year methamphetamine use. Rates (per 1,000 adults aged ≥18 years) for past-year methamphetamine use were estimated overall, by demographic group, and by state. Frequency of past-year use and prevalence of other substance use and mental illness among adults reporting past-year use were assessed. Multivariable logistic regression examined characteristics associated with past-year use. During 2015-2018, the estimated rate of...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
With the rise of the opioid epidemic, stories of addiction and its casualties feature prominently in the media with unprecedented frequency. According to the CDC, in 2016, more than 60,000 individuals died of drug overdose. Though we would like to imagine that this modern-day plague has left youths untouched, research suggests otherwise. According to the authors of Brief Interventions for Adolescent Alcohol and Substance Use, “when considering substance use etiology and interventions, one obvious reason to focus on adolescence is because that’s where the drugs are” (p 17).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Book forum Source Type: research
Abstract BACKGROUND AND OBJECTIVES: Perioperative exposure to opioids is associated with adverse outcomes. We aim to determine the associations between surgery and subsequent opioid overdose, an acute event, and a new diagnosis of opioid use disorder (OUD), a chronic relapsing disease, in parallel. METHODS: This retrospective cohort study of US veterans used surgery as exposure and the two outcomes were (1) occurrence of overdose and (2) new diagnosis of OUD in the first postoperative year. Surgical group was matched to the reference controls based on the propensity score of having surgery, and matched logist...
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research
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Source: Journal of Addictive Diseases - Category: Addiction Authors: Source Type: research
(University of Cincinnati) UC's Health Geography and Disease Modeling Laboratory found that white males ages 30 to 39 were most at risk of fatal overdoses in Ohio. The study also identified 12 clusters in the state where overdose rates were highest.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We present clinical and preclinical evidence supporting a bidirectional relationship between gut microbiota and opioid-related behaviors by highlighting the effects of opioid use on gut bacteria, and the effects of gut bacteria on behavioral responses to opioids. Further, we discuss possible mechanisms of this gut-brain communication influencing opioid use. By clarifying the relationship between the gut microbiome and opioid-related behaviors, we improve understanding on mechanisms mediating reward-, motivation-, and stress-related behaviors and disorders, which may contribute to the development of effective, targeted ther...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Review Articles Source Type: research
CONCLUSION: All five participants were retained at least 1-month postinduction. SCIENTIFIC SIGNIFICANCE: It may be feasible to provide BXR treatment to HPSO-positive heroin users rapidly to achieve clinical stabilization. (Am J Addict 2020;00:00-00). PMID: 32167629 [PubMed - as supplied by publisher]
Source: American Journal on Addictions - Category: Addiction Authors: Tags: Am J Addict Source Type: research
Authors: Mort SC, Díaz SR, Miller C, Bowlby M, Henderson D, Beverly EA Abstract Context: Recreational use of opioids is a growing problem in the United States, particularly in the Midwest. Educators have called for inclusion of pain- and opioid-specific courses in health professional school curricula, yet more research is needed to address future prescribers' beliefs, experiences, and postgraduate plans related to opioids. Objective: To examine health professional students' perceived severity of the opioid crisis and opioid-related beliefs, experiences, and postgraduate plans. Methods: Using a descri...
Source: Journal of the American Osteopathic Association - Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research
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