Adenosine Promotes Human Hair Growth And Inhibits Catagen Transition In Vitro – Role Of The Outer Root Sheath Keratinocytes

Adenosine is a locally produced mediator exerting several cytoprotective effects via G-protein coupled cell membrane adenosine receptors (ARs) (Linden 2005). In the skin, adenosine can influence several (patho)physiological processes, such as wound healing, development of scleroderma, cutaneous inflammation, allergic reactions or barrier formation (Andr és et al. 2017; Burnstock et al. 2012; Silva-Vilches et al. 2019). A beneficial effect of adenosine on hair growth has already been reported in clinical studies: topical adenosine treatment was shown to alleviate the symptoms of alopecia by increasing hair thickness and promoting anagen hair growth (Iwabuchi et al.

Source: Journal of Investigative Dermatology - November 11, 2019 Category: Dermatology Authors: Erika Lisztes, Bal ázs István Tóth, Marta Bertolini, Imre Lőrinc Szabó, Nóra Zákány, Attila Oláh, Attila Gábor Szöllősi, Ralf Paus, Tamás Bíró Tags: Letters to the Editor Source Type: research