Determinants and Prognostic Implications of Left Heart Filling Pressures in Tetralogy of Fallot

Publication date: Available online 11 November 2019Source: Canadian Journal of CardiologyAuthor(s): Alexander C. Egbe, Keerthana Banala, Rahul Vojjini, Maria Najam, Fouad Khalil, Karim Osman, Mohamed Badawy, Jason H. Anderson, Nathaniel W. TaggartAbstractBackgroundElevated pulmonary artery wedge pressure (PAWP) is the hallmark of left heart failure, and is responsible for heart failure symptoms and mortality. Although, PAWP typically correlates with right atrial pressure (RAP), it is primarily dependent on left heart myocardial properties and volume status. Since right heart disease can occur in the absence of left heart disease in patients with tetralogy of Fallot (TOF), we hypothesized that RAP was the primary determinant of PAWP in this population.MethodsA cohort study of adults with TOF that underwent right heart catheterization at Mayo Clinic Rochester (1990-2017) to determine the relationship between RAP, PAWP and mortality.ResultsAmong 213 patients (male 105; age 37±14 years), the mean PAWP was 14±5 mmHg, and RAP was 11±5 mmHg. RAP was the strongest predictor of PAWP (β=0.68, standard error=0.06, p
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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Publication date: Available online 10 December 2019Source: Canadian Journal of CardiologyAuthor(s): Laurie W. Geenen, Vivan J.M. Baggen, Annemien E. van den Bosch, Jannet A. Eindhoven, Robert M. Kauling, Judith A.A.E. Cuypers, Jolien W. Roos-Hesselink, Eric BoersmaAbstractBackgroundSingle high-sensitivity troponin T (hs-TnT) measurement is predictive of cardiac events in adults with congenital heart disease (ACHD). We aimed to study the prognostic value of serial hs-TnT measurements in stable ACHD patients.MethodsIn total, 602 consecutive ACHD patients were enrolled in this prospective study (2011-2013). Blood sampling was...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Conditions:   Hypertension;   Heart Failure;   Hypertensive Heart Disease;   Diastolic Dysfunction Intervention:   Sponsor:   Karolinska Institutet Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We report the case of a 58 ‐year‐old man who presented with New York Heart Association class III heart failure. The work‐up revealed BAV with severe stenosis and severe compromise of left ventricle systolic function. In addition, CoA in the isthmus region, and type B dissection of the aorta were diagnosed.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: IMAGES IN CARDIAC SURGERY Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
SGLT-2 inhibitors and most GLP-1 receptor agonists demonstrated cardiovascular superiority and reduction of cardiovascular and overall mortality. These results stand as a turning point in the management of diabetes, shifting the focus from controlling glucose levels to mastering the extra-glycemic effects of these new drugs. This narrative review will discuss recent CVOT with focus on SGLT-2 inhibitors and GLP-1 receptor agonists to distinguish relevant patients' characteristics as potential predictors for therapeutic efficacy.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
Publication date: Available online 6 December 2019Source: American Journal of Kidney DiseasesAuthor(s): Junichi Ishigami, Yingying Sang, Morgan E. Grams, Josef Coresh, Alex Chang, Kunihiro MatsushitaRationale &ObjectiveInfluenza vaccination is recommended for all adults but particularly for older adults and those with high-risk conditions. Reduced kidney function is an important high-risk condition, but the effectiveness of influenza vaccination across kidney function is uncharacterized. We assessed the effectiveness of influenza vaccination among older adults with and without reduced kidney function.Study DesignObserv...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
BOSTON (CBS) — Mammograms are routinely used to screen for breast cancer in women, but there’s mounting evidence that they may also help identify women at risk for heart disease. Mammograms don’t just detect breast tumors, but can also show calcium deposits in the arteries in the breasts, which has been linked to calcium deposits in the arteries in the heart. Calcium buildup in the coronary arteries is strongly associated with heart disease. Researchers at the University of California San Diego looked at nearly 300 women and found that those with calcified breast arteries were more than twice as likely to...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Dr. Mallika Marshall Health News Heart Disease Heart Failure Mammograms Source Type: news
Recent research suggests that mammograms may help identify women at risk of heart failure by revealing the presence of calcium buildup in breast arteries.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Heart Disease Source Type: news
Authors: Alfarih M, Syrris P, Arbustini E, Augusto JB, Hughes A, Lloyd G, Lopes LR, Moon JC, Mohiddin S, Captur G Abstract In a five-generation family carrying a novel frameshift LMNA variant (c.1434dupG, p.Leu479AlafsX72), imaging-augmented segregation analysis supports its association with lamin heart disease. Affected members exhibit conduction abnormalities, supraventricular and ventricular arrythmias, dilated cardiomyopathy with non-infarct pattern midwall septal fibrosis, heart failure and thromboembolic complications. PMID: 31788659 [PubMed - in process]
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
(Natural News) Managing diabetes is important as it can lead to many complications if left untreated. Leaving your blood sugar levels uncontrolled can take a toll on your cardiovascular health, increasing the risk for heart failure, heart attack, and other cardiovascular events. This is the finding of a study on middle-aged individuals with Type 2...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
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