Angiotensin receptor/neprilysin inhibitor —a breakthrough in chronic heart failure therapy: summary of subanalysis on PARADIGM-HF trial findings

This article includes also recently announced findings on the TRANSITION study which revealed that HFrEF therapy with ARNI might be safely initiated after an acute decompensated heart failure episode, including patients with heart failure de novo and ACEI/ARB na ïve, both hospitalised or shortly after discharge, in contrary to the PARADIGM-HF trial, where patients had to be administered a stable dose of an ACEI/ARB equivalent to enalapril 10 mg a day for at least 4 weeks before the screening.
Source: Heart Failure Reviews - Category: Cardiology Source Type: research

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Conclusions: Patients with ≥1 risk factor had a 30% higher risk for arrhythmia recurrence after ablation, but no differences in risk for repeat ablations, adverse events or death.This article is protected by copyright. All rights reserved
Source: Pacing and Clinical Electrophysiology : PACE - Category: Cardiology Authors: Tags: ELECTROPHYSIOLOGY Source Type: research
Atrial fibrillation (AF) is the most common cardiac arrhythmia observed in clinical practice, and its incidence and prevalence have been progressively increasing with a rise in the aging population and lifestyle changes [1,2]. AF not only affects a patient ’s quality of life due to distressing symptoms but also leads to serious long-term consequences such as stroke and heart failure [3]. The pathophysiology underlying the onset and progression of AF is a complex process that remains unclear despite thorough investigation over the past 3 decades.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
This study aims to determine risk factors for the development of CA in patients undergoing HSCT.Methodology: A retrospective analysis of 138 consecutive patients undergoing HSCT at our institution between January 1st, 2015 and December 31st, 2017 was performed. One patient was excluded due to lack of baseline EKG. Data from patients ≥ 18 y/o who underwent autologous or allogeneic HSCT was analyzed. Variables analyzed included: age, gender, ethnicity, prior HSCT, diagnosis, type of transplant (autologous vs allogeneic), prior anthracycline exposure, diabetes mellitus, chronic kidney disease, hypertension, coronary artery...
Source: Blood - Category: Hematology Authors: Tags: 721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Transplant Toxicities: Poster II Source Type: research
Authors: Cases A, Gorriz JL Abstract Hyperkalemia is one of the most common electrolyte disturbances, especially among some groups of patients, such as in those with chronic kidney disease, diabetes or heart failure. Hyperkalemia has been associated with increased risks of mortality, arrhythmias, hospitalization and costs, as well as the need to down titrate/discontinue renin-angiotensin-aldosterone system inhibitors (RAASIs), despite their well-known cardiovascular and nephroprotective benefits. Current potassium binders have limitations (slow onset of action, limited selectivity for potassium binding, risk of dru...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
Abstract BACKGROUND: Sarcoidosis is an increasingly recognized multi-systemic condition. Cardiac sarcoidosis is associated with ventricular arrhythmias and higher mortality rates. Little epidemiological data is available regarding the disease and associated ventricular arrhythmias. METHODS: Data from the National Inpatient Sample (NIS) database 2012-2014, were reviewed. Discharges associated with sarcoidosis were identified as the target population using relevant ICD-9-CM codes. Primary outcome was a diagnosis of ventricular tachycardia (VT) in the sarcoidosis population. Secondary outcomes include rate of ve...
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
Publication date: June 2018Source: International Journal of Gerontology, Volume 12, Issue 2Author(s): Feng-Ching Liao, Chia-Ying Hsiao, Chuan-Lei Chao, Chun-Han Cheng, Meng-Ruey Wu, Min-I. Su, Chun-Yen Chen, Kung-Te WangSummaryBackgroundThe influence of renal impairment on long-term mortality in Taiwanese patients with an ICD was uncertain. The aim of our study was to examine the impact of moderate to severe CKD on outcome in patients with ICD implantation for secondary prevention in Taiwan.MethodsFrom 2005 to 2013, patients who underwent ICD implantation who were survivors of sudden cardiac arrest or unstable hemodynamics...
Source: International Journal of Gerontology - Category: Geriatrics Source Type: research
Conclusions— Both clinical response and long-term survival were less favorable in patients undergoing CRT upgrade compared to de novo implantations.
Source: Circulation: Arrhythmia and Electrophysiology - Category: Cardiology Authors: Tags: Heart Failure, Mortality/Survival Original Articles Source Type: research
Conclusion: AECOPD patients, with CV risk factors has prolonged length of hospital stay as compared to those without CV risk factors.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 5.1 Airway Pharmacology and Treatment Source Type: research
Publication date: November 2016 Source:Pharmacological Research, Volume 113, Part A Author(s): Patrick Rossignol, Matthieu Legrand, Mikhail Kosiborod, Steven M. Hollenberg, W. Frank Peacock, Michael Emmett, Murray Epstein, Csaba P. Kovesdy, Mehmet Birhan Yilmaz, Wendy Gattis Stough, Etienne Gayat, Bertram Pitt, Faiez Zannad, Alexandre Mebazaa Hyperkalemia is a common electrolyte disorder, especially in chronic kidney disease, diabetes mellitus, or heart failure. Hyperkalemia can lead to potentially fatal cardiac dysrhythmias, and it is associated with increased mortality. Determining whether emergency therapy is warranted...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Abstract Patients with chronic kidney disease and end-stage renal disease are at 5- to 10-fold higher risk for developing cardiovascular disease (CVD) than age-matched controls. Clinically, CVD in this population manifests as coronary artery disease, arrhythmias, stroke, or congestive heart failure. Beyond the traditional risk factors (eg, diabetes mellitus and hypertension), uremia-specific factors that arise from accumulating toxins also contribute to the pathogenesis of CVD. In this review, we summarize the literature on the epidemiology of both traditional and uremia-related CVD and focus on postulated mechani...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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