Cancers, Vol. 11, Pages 1780: Prognostic Factors in a Large Nationwide Cohort of Histologically Confirmed Primary and Secondary Angiosarcomas

This study aimed to analyze AS prognostic factors in a large nationwide cohort of histologically confirmed cases, established through linkage of clinical data from the Netherlands Cancer Registry and pathology data from the Dutch pathology registry (PALGA). All cases were reviewed by an expert pathologist, showing a 16% discordance rate. Multivariable Cox regression survival analysis among 479 confirmed AS patients revealed remarkably poorer overall survival (OS) for primary AS compared to secondary AS (7 vs 21 months, Hazard ratio (HR) = 1.5; 95% confidence interval (CI) = 1.2–1.9). Age above 65 years, male gender, and no surgical treatment also significantly correlated to worse OS. Overall, OS was relatively poor, with a median of 13 months (95% CI = 10–16 months) and 22% five-year survival rate. With this study, we illustrate AS heterogeneity in clinical behavior and show for the first time better survival for secondary AS compared to primary AS.

Source: Cancers - November 11, 2019 Category: Cancer & Oncology Authors: Marije E. Weidema Uta E. Flucke Winette T.A. van der Graaf Vincent K.Y. Ho Melissa H.S. Hillebrandt-Roeffen Dutch Nationwide Network and Registry of Histo- and Cytopathology (PALGA)-Group Dutch Nationwide Network and Registry of Histo- and Cytopathology ( Tags: Article Source Type: research