Varying effects of tyrosine kinase inhibitors on platelet function —A need for individualized CML treatment to minimize the risk for hemostatic and thrombotic complications?

In this study, we show that different TKIs used for treatment of Chronic Myeloid Leukemia have opposing effects on platelet function, with large inter ‐individual differences. Thus, in patients with high risk for hemostatic or thrombotic complications, we suggest that treatment with TKIs should be individualized to minimize risks associated with long‐term treatment. AbstractSince their introduction, tyrosine kinase inhibitors (TKIs, eg, imatinib, nilotinib, dasatinib, bosutinib, ponatinib) have revolutionized the treatment of chronic myeloid leukemia (CML). However, long ‐term treatment with TKIs is associated with serious adverse events including both bleeding and thromboembolism. Experimental studies have shown that TKIs can cause platelet dysfunction. Herein, we present the first side‐by‐side investigation comparing the effects of currently used TKIs on pla telet function and thrombin generation when used in clinically relevant concentrations. A flow cytometry multiparameter protocol was used to study a range of significant platelet activation events (fibrinogen receptor activation, alpha granule, and lysosomal exocytosis, procoagulant membrane exposur e, and mitochondrial permeability changes). In addition, thrombin generation was measured in the presence of TKIs to assess the effects on global hemostasis. Results show that dasatinib generally inhibited platelet function, while bosutinib, nilotinib, and ponatinib showed less consistent effects. I n addition to t...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Marc Arbyn, Elisabete Weiderpass, Laia Bruni, Silvia de Sanjosé, Mona Saraiya, Jacques Ferlay, Freddie BraySummaryBackgroundThe knowledge that persistent human papillomavirus (HPV) infection is the main cause of cervical cancer has resulted in the development of prophylactic vaccines to prevent HPV infection and HPV assays that detect nucleic acids of the virus. WHO has launched a Global Initiative to scale up preventive, screening, and treatment interventions to eliminate cervical cancer as a public health problem during th...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 4 December 2019Source: The Lancet Global HealthAuthor(s): Afsan Bhadelia
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
A new "virtual biopsy" using ultrasound guidance allows doctors to definitively...Read more on AuntMinnie.comRelated Reading: USPSTF again dismisses pancreatic cancer screening New class of radiotracers targets many cancer types Can radiomics detect pancreatic ductal adenocarcinoma? Optical imaging finds small tumors
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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Contributor : Janet L StanfordSeries Type : Expression profiling by arrayOrganism : Homo sapiensPrognostic biomarkers are useful to screen patients with clinically localized prostate cancer (PCa) who are at high risk of metastatic progression. The tumor transcriptome can be used to evaluate the aggressiveness of PCa and predict adverse patient outcomes. Genomewide gene expression levels were measured in primary tumor samples of 503 patients in a population ‐based cohort.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
This study demonstrated that a homogeneous polysaccharide (HPS) extracted from Hawthorn exerted anti-cancer effects on colon cancer cells. Human colon cancer cell line HCT116 were treated with 125–1000 µg/mL HPS for 12 h and subsequent analysis was performed on proliferation and signaling pathways. HPS significantly inhibited proliferation of HCT116 cells when analyzed using WST-1 assay and immunofluorescence staining of Ki-67. Flow cytometric studies revealed that HPS could arrest the cell cycle in the S and G2/M phases and increase the rate of apoptosis. HPS downregulated the expression of Cyclin A1...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
This study assessed dark sweet cherry (DSC) phenolics as chemopreventive/chemotherapeutics against aggressive breast cancer subtypes.DSC phenolics in whole extract (WE) and fractions enriched in phenolic acids (F1), flavonols (F3) and proanthocyanidins (F4) inhibited breast cancer cell growth with potency MDA-MB-453 > MDA-MB-231 ∼ BT-474, without toxicity to MCF-10A normal breast cells, except F3 that inhibited BT-474 and MCF-10A cells with similar toxicity. DSC anthocyanins (F2) inhibited breast cancer cell lines with similar potencies without toxicity to MCF-10A cells.Mechanisms for WE, F2 and F4 breast an...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
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